|Other Names||Wnt inhibitory factor 1, WIF-1, WIF1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Binds to WNT proteins and inhibits their activities. May be involved in mesoderm segmentation.|
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The protein encoded by this gene functions to inhibit WNTproteins, which are extracellular signaling molecules that play arole in embryonic development. This protein contains a WNTinhibitory factor (WIF) domain and five epidermal growth factor(EGF)-like domains, and is thought to be involved in mesodermsegmentation. This gene functions as a tumor suppressor gene, andhas been found to be epigenetically silenced in various cancers.
Licchesi, J.D., et al. Oncogene 29(44):5923-5934(2010)Fendri, A., et al. Cancer Invest. 28(9):896-903(2010)Kohno, H., et al. Oncol. Rep. 24(2):423-431(2010)Belshaw, N.J., et al. Carcinogenesis 31(6):1158-1163(2010)Costa, V.L., et al. Epigenetics 5(4):343-351(2010)
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