|Other Names||Wnt inhibitory factor 1, WIF-1, WIF1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Binds to WNT proteins and inhibits their activities. May be involved in mesoderm segmentation.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene functions to inhibit WNTproteins, which are extracellular signaling molecules that play arole in embryonic development. This protein contains a WNTinhibitory factor (WIF) domain and five epidermal growth factor(EGF)-like domains, and is thought to be involved in mesodermsegmentation. This gene functions as a tumor suppressor gene, andhas been found to be epigenetically silenced in various cancers.
Licchesi, J.D., et al. Oncogene 29(44):5923-5934(2010)Fendri, A., et al. Cancer Invest. 28(9):896-903(2010)Kohno, H., et al. Oncol. Rep. 24(2):423-431(2010)Belshaw, N.J., et al. Carcinogenesis 31(6):1158-1163(2010)Costa, V.L., et al. Epigenetics 5(4):343-351(2010)
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