|Other Names||Serine/threonine-protein phosphatase 6 catalytic subunit, PP6C, Serine/threonine-protein phosphatase 6 catalytic subunit, N-terminally processed, PPP6C, PPP6|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Catalytic subunit of protein phosphatase 6 (PP6). PP6 is a component of a signaling pathway regulating cell cycle progression in response to IL2 receptor stimulation. N-terminal domain restricts G1 to S phase progression in cancer cells, in part through control of cyclin D1. Downregulates MAP3K7 kinase activation of the IL1 signaling pathway by dephosphorylation of MAP3K7.|
|Tissue Location||Ubiquitously expressed in all tissues tested with highest expression levels in testis, heart, kidney, brain, stomach, liver and skeletal muscle and lowest in placenta, lung colon and spleen.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes the catalytic subunit of proteinphosphatase, a component of a signaling pathway regulating cellcycle progression. Splice variants encoding different proteinisoforms exist. The pseudogene of this gene is located onchromosome X.
Douglas, P., et al. Mol. Cell. Biol. 30(6):1368-1381(2010)Dema, B., et al. Genes Immun. 10(7):659-661(2009)Morales-Johansson, H., et al. PLoS ONE 4 (7), E6331 (2009) :Mi, J., et al. PLoS ONE 4 (2), E4395 (2009) :Stefansson, B., et al. Biochemistry 47(5):1442-1451(2008)
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