PPP6C Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | O00743 |
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Clone Names | 100507139 |
Gene ID | 5537 |
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Other Names | Serine/threonine-protein phosphatase 6 catalytic subunit, PP6C, Serine/threonine-protein phosphatase 6 catalytic subunit, N-terminally processed, PPP6C, PPP6 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | PPP6C {ECO:0000303|PubMed:29053956, ECO:0000312|HGNC:HGNC:9323} |
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Function | Catalytic subunit of protein phosphatase 6 (PP6) (PubMed:17079228, PubMed:29053956, PubMed:32474700). PP6 is a component of a signaling pathway regulating cell cycle progression in response to IL2 receptor stimulation (PubMed:10227379). N-terminal domain restricts G1 to S phase progression in cancer cells, in part through control of cyclin D1 (PubMed:17568194). During mitosis, regulates spindle positioning (PubMed:27335426). Down-regulates MAP3K7 kinase activation of the IL1 signaling pathway by dephosphorylation of MAP3K7 (PubMed:17079228). Participates also in the innate immune defense against viruses by desphosphorylating RIGI, an essential step that triggers RIGI-mediated signaling activation (PubMed:29053956). Also regulates innate immunity by acting as a negative regulator of the cGAS-STING pathway: mediates dephosphorylation and inactivation of CGAS and STING1 (PubMed:32753499, PubMed:32474700). CGAS dephosphorylation at 'Ser-435' impairs its ability to bind GTP, thereby inactivating it (PubMed:32474700). |
Cellular Location | Mitochondrion. Cytoplasm |
Tissue Location | Ubiquitously expressed in all tissues tested with highest expression levels in testis, heart, kidney, brain, stomach, liver and skeletal muscle and lowest in placenta, lung colon and spleen. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes the catalytic subunit of proteinphosphatase, a component of a signaling pathway regulating cellcycle progression. Splice variants encoding different proteinisoforms exist. The pseudogene of this gene is located onchromosome X.
References
Douglas, P., et al. Mol. Cell. Biol. 30(6):1368-1381(2010)Dema, B., et al. Genes Immun. 10(7):659-661(2009)Morales-Johansson, H., et al. PLoS ONE 4 (7), E6331 (2009) :Mi, J., et al. PLoS ONE 4 (2), E4395 (2009) :Stefansson, B., et al. Biochemistry 47(5):1442-1451(2008)
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