|Other Names||Serine/threonine-protein phosphatase 6 catalytic subunit, PP6C, Serine/threonine-protein phosphatase 6 catalytic subunit, N-terminally processed, PPP6C, PPP6|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Catalytic subunit of protein phosphatase 6 (PP6). PP6 is a component of a signaling pathway regulating cell cycle progression in response to IL2 receptor stimulation. N-terminal domain restricts G1 to S phase progression in cancer cells, in part through control of cyclin D1. Downregulates MAP3K7 kinase activation of the IL1 signaling pathway by dephosphorylation of MAP3K7. Participates also in the innate immune defense against viruses by desphosphorylating RIG-I/DDX58, an essential step that triggers RIG-I/DDX58-mediated signaling activation.|
|Cellular Location||Mitochondrion. Cytoplasm|
|Tissue Location||Ubiquitously expressed in all tissues tested with highest expression levels in testis, heart, kidney, brain, stomach, liver and skeletal muscle and lowest in placenta, lung colon and spleen.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes the catalytic subunit of proteinphosphatase, a component of a signaling pathway regulating cellcycle progression. Splice variants encoding different proteinisoforms exist. The pseudogene of this gene is located onchromosome X.
Douglas, P., et al. Mol. Cell. Biol. 30(6):1368-1381(2010)Dema, B., et al. Genes Immun. 10(7):659-661(2009)Morales-Johansson, H., et al. PLoS ONE 4 (7), E6331 (2009) :Mi, J., et al. PLoS ONE 4 (2), E4395 (2009) :Stefansson, B., et al. Biochemistry 47(5):1442-1451(2008)
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