|Other Names||Sialic acid-binding Ig-like lectin 8, Siglec-8, Sialoadhesin family member 2, SAF-2, SIGLEC8, SAF2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Putative adhesion molecule that mediates sialic-acid dependent binding to red blood cells (PubMed:10856141, PubMed:10625619). Preferentially binds to alpha-2,3-linked sialic acid. Also binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface (PubMed:10625619). Recognizes simultaneously epitopes having a terminal N-acetylneuraminic acid (sialic acid) and an underlying 6-O-sulfated galactose. Preferentially binds to Gal-6-sulfated sialyl-Lewis X glycan epitopes (PubMed:27357658).|
|Cellular Location||Membrane; Single-pass type I membrane protein|
|Tissue Location||Expressed specifically on red blood cells namely basophil, mast cells and eosinophils|
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Provided below are standard protocols that you may find useful for product applications.
Sialic acid-binding immunoglobulin (Ig)-like lectins, orSIGLECs (e.g., CD33 (MIM 159590)), are a family of type 1transmembrane proteins each having a unique expression pattern,mostly in hemopoietic cells. SIGLEC8 is a member of the CD33-likesubgroup of SIGLECs, which are localized to 19q13.3-q13.4 and have2 conserved cytoplasmic tyrosine-based motifs: an immunoreceptortyrosine-based inhibitory motif, or ITIM (see MIM 604964), and amotif homologous to one identified in signaling lymphocyteactivation molecule (SLAM; MIM 603492) that mediates an associationwith SLAM-associated protein (SAP; MIM 300490) (summarized byFoussias et al., 2000 [PubMed 11095983]).
Gao, P.S., et al. Eur. J. Hum. Genet. 18(6):713-719(2010)Davila, S., et al. Genes Immun. 11(3):232-238(2010)Hudson, S.A., et al. J. Pharmacol. Exp. Ther. 330(2):608-612(2009)Bochner, B.S. Clin. Exp. Allergy 39(3):317-324(2009)von Gunten, S., et al. Autoimmun Rev 7(6):453-456(2008)
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