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SIGLEC8 Antibody (N-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q9NYZ4
Clone Names 100507146
Peptide ID 100507146
Additional Information
Gene ID 27181
Other Names Sialic acid-binding Ig-like lectin 8, Siglec-8, Sialoadhesin family member 2, SAF-2, SIGLEC8, SAF2
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name SIGLEC8
Synonyms SAF2
Function Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- linked sialic acid. Also binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.
Cellular Location Membrane; Single-pass type I membrane protein
Tissue Location Expressed specifically on eosinophils.
Research Areas
Citations (0)

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Background

Sialic acid-binding immunoglobulin (Ig)-like lectins, orSIGLECs (e.g., CD33 (MIM 159590)), are a family of type 1transmembrane proteins each having a unique expression pattern,mostly in hemopoietic cells. SIGLEC8 is a member of the CD33-likesubgroup of SIGLECs, which are localized to 19q13.3-q13.4 and have2 conserved cytoplasmic tyrosine-based motifs: an immunoreceptortyrosine-based inhibitory motif, or ITIM (see MIM 604964), and amotif homologous to one identified in signaling lymphocyteactivation molecule (SLAM; MIM 603492) that mediates an associationwith SLAM-associated protein (SAP; MIM 300490) (summarized byFoussias et al., 2000 [PubMed 11095983]).

References

Gao, P.S., et al. Eur. J. Hum. Genet. 18(6):713-719(2010)Davila, S., et al. Genes Immun. 11(3):232-238(2010)Hudson, S.A., et al. J. Pharmacol. Exp. Ther. 330(2):608-612(2009)Bochner, B.S. Clin. Exp. Allergy 39(3):317-324(2009)von Gunten, S., et al. Autoimmun Rev 7(6):453-456(2008)

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$ 80.00
Cat# BP14564a
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