|Other Names||Retinal homeobox protein Rx, Retina and anterior neural fold homeobox protein, RAX, RX|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Plays a critical role in eye formation by regulating the initial specification of retinal cells and/or their subsequent proliferation. Binds to the photoreceptor conserved element-I (PCE-1/Ret 1) in the photoreceptor cell-specific arrestin promoter.|
|Tissue Location||Expressed in the developing eye and weakly expressed in the adult retina|
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This gene encodes a homeobox-containing transcriptionfactor that functions in eye development. The gene is expressedearly in the eye primordia, and is required for retinal cell fatedetermination and also regulates stem cell proliferation. Mutationsin this gene have been reported in patients with defects in oculardevelopment, including microphthalmia, anophthalmia, and coloboma.
Gonzalez-Rodriguez, J., et al. Br J Ophthalmol 94(8):1100-1104(2010)Chassaing, N., et al. Genet Test Mol Biomarkers 13(3):289-290(2009)Zhang, X., et al. Mol. Vis. 15, 2911-2918 (2009) :London, N.J., et al. Mol. Vis. 15, 162-167 (2009) :Voronina, V.A., et al. Hum. Mol. Genet. 13(3):315-322(2004)
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