|Other Names||Testis-specific serine kinase substrate, Testis-specific kinase substrate, STK22 substrate 1, TSKS, STK22S1, TSKS1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May play a role in testicular physiology, most probably in the process of spermatogenesis or spermatid development.|
|Cellular Location||Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=Concentrates in spermatid centrioles during flagellogenesis|
|Tissue Location||Highly expressed in testis. Expressed at low levels in prostate, female breast, placenta, ovary and thymus|
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This gene may play a role in testicular physiology,spermatogenesis or spermiogenesis. Expression of the encodedprotein is highest in the testis and down-regulated in testicularcancer. The gene is localized to the region 19q13.3 among therelated RAS viral oncogene homolog (RRAS) and interferon regulatoryfactor 3 (IRF3) genes, which are both involved in tumorigenesispathways and progression.
Xu, B., et al. Dev. Biol. 319(2):201-210(2008)Wu, C., et al. Proteomics 7(11):1775-1785(2007)Hao, Z., et al. Mol. Hum. Reprod. 10(6):433-444(2004)Scorilas, A., et al. Biochem. Biophys. Res. Commun. 285(2):400-408(2001)
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