|Other Names||NAD-dependent protein deacetylase sirtuin-3, mitochondrial, hSIRT3, 351-, Regulatory protein SIR2 homolog 3, SIR2-like protein 3, SIRT3, SIR2L3|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||NAD-dependent protein deacetylase. Activates or deactivates mitochondrial target proteins by deacetylating key lysine residues. Known targets include ACSS1, IDH, GDH, SOD2, PDHA1, LCAD, SDHA and the ATP synthase subunit ATP5O. Contributes to the regulation of the cellular energy metabolism. Important for regulating tissue-specific ATP levels.|
|Cellular Location||Mitochondrion matrix|
|Tissue Location||Widely expressed.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
firstname.lastname@example.org, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the sirtuin family ofproteins, homologs to the yeast Sir2 protein. Members of thesirtuin family are characterized by a sirtuin core domain andgrouped into four classes. The functions of human sirtuins have notyet been determined; however, yeast sirtuin proteins are known toregulate epigenetic gene silencing and suppress recombination ofrDNA. Studies suggest that the human sirtuins may function asintracellular regulatory proteins with mono-ADP-ribosyltransferaseactivity. The protein encoded by this gene is included in class Iof the sirtuin family. Two alternatively spliced transcriptvariants that encode different proteins have been described forthis gene.
Dransfeld, C.L., et al. Int. J. Oncol. 36(4):955-960(2010)Shulga, N., et al. J. Cell. Sci. 123 (PT 6), 894-902 (2010) :Shi, T., et al. J Dig Dis 11(1):55-62(2010)Kong, X., et al. PLoS ONE 5 (7), E11707 (2010) :Li, S., et al. PLoS ONE 5 (5), E10486 (2010) :
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at email@example.com.