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SIRT5 Antibody (Center) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q9NXA8
Clone Names 100507187
Peptide ID 100507187
Additional Information
Gene ID 23408
Other Names NAD-dependent protein deacylase sirtuin-5, mitochondrial {ECO:0000255|HAMAP-Rule:MF_03160}, 351- {ECO:0000255|HAMAP-Rule:MF_03160}, Regulatory protein SIR2 homolog 5 {ECO:0000255|HAMAP-Rule:MF_03160}, SIR2-like protein 5 {ECO:0000255|HAMAP-Rule:MF_03160}, SIRT5 {ECO:0000255|HAMAP-Rule:MF_03160}, SIR2L5
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name SIRT5 {ECO:0000255|HAMAP-Rule:MF_03160}
Synonyms SIR2L5
Function NAD-dependent lysine demalonylase and desuccinylase that specifically removes malonyl and succinyl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. Can deacetylate cytochrome c (CYCS) and a number of other proteins in vitro.
Cellular Location Mitochondrion matrix. Mitochondrion intermembrane space. Cytoplasm, cytosol. Nucleus. Note=Mainly mitochondrial. Also present extramitochondrially: a fraction is present in the cytosol and very small amounts are also detected in the nucleus Isoform 2: Mitochondrion {ECO:0000255|HAMAP- Rule:MF_03160, ECO:0000269|PubMed:21143562}
Tissue Location Widely expressed.
Research Areas
Citations (0)

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This gene encodes a member of the sirtuin family ofproteins, homologs to the yeast Sir2 protein. Members of thesirtuin family are characterized by a sirtuin core domain andgrouped into four classes. The functions of human sirtuins have notyet been determined; however, yeast sirtuin proteins are known toregulate epigenetic gene silencing and suppress recombination ofrDNA. Studies suggest that the human sirtuins may function asintracellular regulatory proteins with mono-ADP-ribosyltransferaseactivity. The protein encoded by this gene is included in class IIIof the sirtuin family. Alternative splicing of this gene results inmultiple transcript variants.


Schlicker, C., et al. J. Mol. Biol. 382(3):790-801(2008)Yamamoto, H., et al. Mol. Endocrinol. 21(8):1745-1755(2007)Chowdari, K.V., et al. Genes Brain Behav. 6(3):229-239(2007)Mahlknecht, U., et al. Cytogenet. Genome Res. 112 (3-4), 208-212 (2006) :Michishita, E., et al. Mol. Biol. Cell 16(10):4623-4635(2005)

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$ 80.00
Cat# BP14574c
(40 western blots)
Availability: In Stock
Bulk Size
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