|Other Names||Glycodelin, GD, Placental protein 14, PP14, Pregnancy-associated endometrial alpha-2 globulin, PAEG, PEG, Progestagen-associated endometrial protein, Progesterone-associated endometrial protein, PAEP|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||This protein is, quantitatively, the main protein synthesized and secreted in the endometrium from mid-luteal phase of the menstrual cycle and during the first semester of pregnancy.|
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This gene is a member of the kernel lipocalin superfamilywhose members share relatively low sequence similarity but havehighly conserved exon/intron structure and three-dimensionalprotein folding. Most lipocalins are clustered on the long arm ofchromosome 9. The encoded glycoprotein has been previously referredto as pregnancy-associated endometrial alpha-2-globulin, placentalprotein 14, and glycodelin, but has been officially namedprogestagen-associated endometrial protein. Three distinct forms,with identical protein backbones but different glycosylationprofiles, are found in amniotic fluid, follicular fluid and seminalplasma of the reproductive system. These glycoproteins havedistinct and essential roles in regulating a uterine environmentsuitable for pregnancy and in the timing and occurrence of theappropriate sequence of events in the fertilization process. Anumber of alternatively spliced transcript variants have beenobserved at this locus, but the full-length nature of only two,each encoding the same protein, has been determined. [provided byRefSeq].
Soni, C., et al. Mol. Immunol. 47(15):2458-2466(2010)Lee, C.L., et al. Fertil. Steril. 94(2):769-771(2010)Tsviliana, A., et al. Anticancer Res. 30(5):1637-1640(2010)Scholz, C., et al. Anticancer Res. 30(5):1599-1603(2010)Amir, M., et al. Reprod. Biol. Endocrinol. 7, 152 (2009) :
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