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ADRA2C Antibody (C-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession P18825
Clone Names 100507228
Peptide ID 100507228
Additional Information
Gene ID 152
Other Names Alpha-2C adrenergic receptor, Alpha-2 adrenergic receptor subtype C4, Alpha-2C adrenoreceptor, Alpha-2C adrenoceptor, Alpha-2CAR, ADRA2C, ADRA2L2, ADRA2RL2
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms ADRA2L2, ADRA2RL2
Function Alpha-2 adrenergic receptors mediate the catecholamine- induced inhibition of adenylate cyclase through the action of G proteins.
Cellular Location Cell membrane; Multi-pass membrane protein.
Research Areas
Citations (0)

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Alpha-2-adrenergic receptors are members of the Gprotein-coupled receptor superfamily. They include 3 highlyhomologous subtypes: alpha2A, alpha2B, and alpha2C. These receptorshave a critical role in regulating neurotransmitter release fromsympathetic nerves and from adrenergic neurons in the centralnervous system. The mouse studies revealed that both the alpha2Aand alpha2C subtypes were required for normal presynaptic controlof transmitter release from sympathetic nerves in the heart andfrom central noradrenergic neurons. The alpha2A subtype inhibitedtransmitter release at high stimulation frequencies, whereas thealpha2C subtype modulated neurotransmission at lower levels ofnerve activity. This gene encodes the alpha2C subtype, whichcontains no introns in either its coding or untranslated sequences.


Chen, Q.J., et al. Clin. Biochem. 43(15):1201-1204(2010)Maqbool, A., et al. J. Hypertens. 28(10):2084-2093(2010)Saus, E., et al. J Psychiatr Res 44(14):971-978(2010)Gao, Y., et al. Ophthalmology (2010) In press :Montgomery, M.D., et al. Br. J. Pharmacol. 159(4):820-830(2010)

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$ 80.00
Cat# BP14582b
Availability: In Stock
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