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U2AF2 Antibody (N-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession P26368
Clone Names 100507230
Peptide ID 100507230
Additional Information
Gene ID 11338
Other Names Splicing factor U2AF 65 kDa subunit, U2 auxiliary factor 65 kDa subunit, hU2AF(65), hU2AF65, U2 snRNP auxiliary factor large subunit, U2AF2, U2AF65
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name U2AF2
Synonyms U2AF65
Function Plays a role in pre-mRNA splicing and 3'-end processing (PubMed:17024186). By recruiting PRPF19 and the PRP19C/Prp19 complex/NTC/Nineteen complex to the RNA polymerase II C-terminal domain (CTD), and thereby pre-mRNA, may couple transcription to splicing (PubMed:21536736). Induces cardiac troponin-T (TNNT2) pre-mRNA exon inclusion in muscle. Regulates the TNNT2 exon 5 inclusion through competition with MBNL1. Binds preferentially to a single-stranded structure within the polypyrimidine tract of TNNT2 intron 4 during spliceosome assembly. Required for the export of mRNA out of the nucleus, even if the mRNA is encoded by an intron-less gene. Represses the splicing of MAPT/Tau exon 10. Positively regulates pre-mRNA 3'-end processing by recruiting the CFIm complex to cleavage and polyadenylation signals (PubMed:17024186).
Cellular Location Nucleus.
Research Areas
Citations (0)

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U2 auxiliary factor (U2AF), comprised of a large and asmall subunit, is a non-snRNP protein required for the binding ofU2 snRNP to the pre-mRNA branch site. This gene encodes the U2AFlarge subunit which contains a sequence-specific RNA-binding regionwith 3 RNA recognition motifs and an Arg/Ser-rich domain necessaryfor splicing. The large subunit binds to the polypyrimidine tractof introns early during spliceosome assembly. Multiple transcriptvariants have been detected for this gene, but the full-lengthnatures of only two have been determined to date. [provided byRefSeq].


Webby, C.J., et al. Science 325(5936):90-93(2009)Martins de Araujo, M., et al. RNA 15(4):515-523(2009)Corsini, L., et al. J. Biol. Chem. 284(1):630-639(2009)Jenkins, J.L., et al. J. Biol. Chem. 283(48):33641-33649(2008)Izquierdo, J.M. Mol. Biol. Cell 19(8):3299-3307(2008)

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$ 80.00
Cat# BP14583a
Availability: In Stock
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