PSMC2 Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | P35998 |
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Clone Names | 100507233 |
Gene ID | 5701 |
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Other Names | 26S protease regulatory subunit 7, 26S proteasome AAA-ATPase subunit RPT1, Proteasome 26S subunit ATPase 2, Protein MSS1, PSMC2, MSS1 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | PSMC2 |
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Synonyms | MSS1 {ECO:0000303|PubMed:8500623} |
Function | Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC2 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides. |
Cellular Location | Cytoplasm. Note=Colocalizes with TRIM5 in cytoplasmic bodies |
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Provided below are standard protocols that you may find useful for product applications.
Background
The 26S proteasome is a multicatalytic proteinase complexwith a highly ordered structure composed of 2 complexes, a 20S coreand a 19S regulator. The 20S core is composed of 4 rings of 28non-identical subunits; 2 rings are composed of 7 alpha subunitsand 2 rings are composed of 7 beta subunits. The 19S regulator iscomposed of a base, which contains 6 ATPase subunits and 2non-ATPase subunits, and a lid, which contains up to 10 non-ATPasesubunits. Proteasomes are distributed throughout eukaryotic cellsat a high concentration and cleave peptides in anATP/ubiquitin-dependent process in a non-lysosomal pathway. Anessential function of a modified proteasome, the immunoproteasome,is the processing of class I MHC peptides. This gene encodes one ofthe ATPase subunits, a member of the triple-A family of ATPaseswhich have a chaperone-like activity. This subunit has been shownto interact with several of the basal transcription factors so, inaddition to participation in proteasome functions, this subunit mayparticipate in the regulation of transcription. This subunit mayalso compete with PSMC3 for binding to the HIV tat protein toregulate the interaction between the viral protein and thetranscription complex.
References
Kaneko, T., et al. Cell 137(5):914-925(2009)Tu, L.C., et al. Mol. Cell Proteomics 6(4):575-588(2007)Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :Guo, D., et al. Biochem. Biophys. Res. Commun. 337(4):1308-1318(2005)Bruneel, A., et al. Proteomics 5(15):3876-3884(2005)
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