|Other Names||26S protease regulatory subunit 7, 26S proteasome AAA-ATPase subunit RPT1, Proteasome 26S subunit ATPase 2, Protein MSS1, PSMC2, MSS1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex. In case of HIV-1 infection, positive modulator of Tat-mediated transactivation.|
|Cellular Location||Cytoplasm. Nucleus. Cytoplasm, P-body. Note=Colocalizes with TRIM5 in the cytoplasmic bodies.|
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Provided below are standard protocols that you may find useful for product applications.
The 26S proteasome is a multicatalytic proteinase complexwith a highly ordered structure composed of 2 complexes, a 20S coreand a 19S regulator. The 20S core is composed of 4 rings of 28non-identical subunits; 2 rings are composed of 7 alpha subunitsand 2 rings are composed of 7 beta subunits. The 19S regulator iscomposed of a base, which contains 6 ATPase subunits and 2non-ATPase subunits, and a lid, which contains up to 10 non-ATPasesubunits. Proteasomes are distributed throughout eukaryotic cellsat a high concentration and cleave peptides in anATP/ubiquitin-dependent process in a non-lysosomal pathway. Anessential function of a modified proteasome, the immunoproteasome,is the processing of class I MHC peptides. This gene encodes one ofthe ATPase subunits, a member of the triple-A family of ATPaseswhich have a chaperone-like activity. This subunit has been shownto interact with several of the basal transcription factors so, inaddition to participation in proteasome functions, this subunit mayparticipate in the regulation of transcription. This subunit mayalso compete with PSMC3 for binding to the HIV tat protein toregulate the interaction between the viral protein and thetranscription complex.
Kaneko, T., et al. Cell 137(5):914-925(2009)Tu, L.C., et al. Mol. Cell Proteomics 6(4):575-588(2007)Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :Guo, D., et al. Biochem. Biophys. Res. Commun. 337(4):1308-1318(2005)Bruneel, A., et al. Proteomics 5(15):3876-3884(2005)
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