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NR1I3 Antibody (Center) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q14994
Clone Names 100507240
Peptide ID 100507240
Additional Information
Gene ID 9970
Other Names Nuclear receptor subfamily 1 group I member 3, Constitutive activator of retinoid response, Constitutive active response, Constitutive androstane receptor, CAR, Orphan nuclear receptor MB67, NR1I3, CAR
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name NR1I3
Synonyms CAR
Function Binds and transactivates the retinoic acid response elements that control expression of the retinoic acid receptor beta 2 and alcohol dehydrogenase 3 genes. Transactivates both the phenobarbital responsive element module of the human CYP2B6 gene and the CYP3A4 xenobiotic response element.
Cellular Location Nucleus. Cytoplasm. Cytoplasm, cytoskeleton. Note=Recruited to the cytoplasm by DNAJC7.
Tissue Location Predominantly expressed in liver.
Research Areas
Citations (0)

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This gene encodes a member of the nuclear receptorsuperfamily, and is a key regulator of xenobiotic and endobioticmetabolism. The protein binds to DNA as a monomer or a heterodimerwith the retinoid X receptor and regulates the transcription oftarget genes involved in drug metabolism and bilirubin clearance,such as cytochrome P450 family members. Unlike most nuclearreceptors, this transcriptional regulator is constitutively activein the absence of ligand but is regulated by both agonists andinverse agonists. Ligand binding results in translocation of thisprotein to the nucleus, where it activates or represses target genetranscription. These ligands include bilirubin, a variety offoreign compounds, steroid hormones, and prescription drugs.Multiple transcript variants encoding different isoforms have beenfound for this gene.


Benet, M., et al. J. Biol. Chem. 285(37):28457-28471(2010)Oliver, P., et al. Clin. Chem. Lab. Med. 48(5):635-639(2010)Masuyama, H., et al. Mol. Endocrinol. 24(4):745-753(2010)Mutoh, S., et al. J. Biol. Chem. 284(50):34785-34792(2009)Urano, T., et al. Geriatr Gerontol Int 9(3):235-241(2009)

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$ 80.00
Cat# BP14587c
Availability: In Stock
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