|Other Names||Calcium release-activated calcium channel protein 1, Protein orai-1, Transmembrane protein 142A, ORAI1, CRACM1, TMEM142A|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Ca(2+) release-activated Ca(2+) (CRAC) channel subunit which mediates Ca(2+) influx following depletion of intracellular Ca(2+) stores and channel activation by the Ca(2+) sensor, STIM1 (PubMed:16582901, PubMed:16645049, PubMed:16733527, PubMed:16766533, PubMed:16807233, PubMed:19249086, PubMed:23307288, PubMed:24351972, PubMed:24591628). CRAC channels are the main pathway for Ca(2+) influx in T-cells and promote the immune response to pathogens by activating the transcription factor NFAT (PubMed:16582901).|
|Cellular Location||Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle, autophagosome. Note=Isoform beta is more mobile in the plasma membrane. Colocalizes with UBQLN1 in the autophagosome|
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Provided below are standard protocols that you may find useful for product applications.
CRACM1 is a plasma membrane protein essential forstore-operated calcium entry (Vig et al., 2006 [PubMed16645049]).
Feng, M., et al. Cell 143(1):84-98(2010)Kawasaki, T., et al. J. Biol. Chem. 285(33):25720-25730(2010)Motiani, R.K., et al. J. Biol. Chem. 285(25):19173-19183(2010)Zhou, Y., et al. Proc. Natl. Acad. Sci. U.S.A. 107(11):4896-4901(2010)Bogeski, I., et al. Sci Signal 3 (115), RA24 (2010) :
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