|Other Names||Calcium release-activated calcium channel protein 1, Protein orai-1, Transmembrane protein 142A, ORAI1, CRACM1, TMEM142A|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Ca(2+) release-activated Ca(2+) (CRAC) channel subunit which mediates Ca(2+) influx following depletion of intracellular Ca(2+) stores and channel activation by the Ca(2+) sensor, STIM1 (PubMed:16582901, PubMed:16645049, PubMed:16733527, PubMed:16766533, PubMed:16807233, PubMed:19249086, PubMed:23307288, PubMed:24351972, PubMed:24591628). CRAC channels are the main pathway for Ca(2+) influx in T-cells and promote the immune response to pathogens by activating the transcription factor NFAT (PubMed:16582901).|
|Cellular Location||Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle, autophagosome. Note=Isoform beta is more mobile in the plasma membrane. Colocalizes with UBQLN1 in the autophagosome|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
email@example.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
CRACM1 is a plasma membrane protein essential forstore-operated calcium entry (Vig et al., 2006 [PubMed16645049]).
Feng, M., et al. Cell 143(1):84-98(2010)Kawasaki, T., et al. J. Biol. Chem. 285(33):25720-25730(2010)Motiani, R.K., et al. J. Biol. Chem. 285(25):19173-19183(2010)Zhou, Y., et al. Proc. Natl. Acad. Sci. U.S.A. 107(11):4896-4901(2010)Bogeski, I., et al. Sci Signal 3 (115), RA24 (2010) :
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at firstname.lastname@example.org.