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PSMA1 Antibody (C-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession P25786
Clone Names 100507243
Peptide ID 100507243
Additional Information
Gene ID 5682
Other Names Proteasome subunit alpha type-1, 30 kDa prosomal protein, PROS-30, Macropain subunit C2, Multicatalytic endopeptidase complex subunit C2, Proteasome component C2, Proteasome nu chain, PSMA1, HC2, NU, PROS30, PSC2
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name PSMA1
Synonyms HC2, NU, PROS30, PSC2
Function Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).
Cellular Location Cytoplasm. Nucleus
Research Areas
Citations (0)

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Background

The proteasome is a multicatalytic proteinase complex witha highly ordered ring-shaped 20S core structure. The core structureis composed of 4 rings of 28 non-identical subunits; 2 rings arecomposed of 7 alpha subunits and 2 rings are composed of 7 betasubunits. Proteasomes are distributed throughout eukaryotic cellsat a high concentration and cleave peptides in anATP/ubiquitin-dependent process in a non-lysosomal pathway. Anessential function of a modified proteasome, the immunoproteasome,is the processing of class I MHC peptides. This gene encodes amember of the peptidase T1A family, that is a 20S core alphasubunit. Alternative splicing results in multiple transcriptvariants encoding distinct isoforms.

References

Zhang, Y., et al. Biochem. Biophys. Res. Commun. 355(1):245-251(2007)Apcher, G.S., et al. FEBS Lett. 569 (1-3), 211-216 (2004) :Jayarapu, K., et al. Biochem. Biophys. Res. Commun. 314(2):523-528(2004)Apcher, G.S., et al. FEBS Lett. 553 (1-2), 200-204 (2003) :Huang, X., et al. J. Mol. Biol. 323(4):771-782(2002)

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$ 80.00
Cat# BP14589b
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