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SCGN Antibody (N-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession O76038
Clone Names 70319115
Additional Information
Other Names Secretagogin, SCGN, SECRET
Target/Specificity The synthetic peptide sequence used to generate the antibody AP1458a was selected from the N-term region of human SCGN. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name SCGN
Synonyms SECRET
Cellular Location Cytoplasm. Secreted. Cytoplasmic vesicle, secretory vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Note=Predominantly cytoplasmic. A small proportion is associated with secretory granules and membrane fractions (By similarity). Detectable in human serum after ischemic neuronal damage.
Tissue Location Expressed at high levels in the pancreatic islets of Langerhans and to a much lesser extent in the gastrointestinal tract (stomach, small intestine and colon), the adrenal medulla and cortex and the thyroid C-cells. In the brain, the expression is restricted to distinct subtypes of neurons with highest expression in the molecular layer of the cerebellum (stellate and basket cells), in the anterior part of the pituitary gland, in the thalamus, in the hypothalamus and in a subgroup of neocortical neurons. EMBL; Y16752; CAA76365.1; -; mRNA EMBL; AK289477; BAF82166.1; -; mRNA EMBL; AL512384; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL; AL022170; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL; CH471087; EAW55487.1; -; Genomic_DNA EMBL; BC000336; AAH00336.1; -; mRNA EMBL; BC003036; AAH03036.1; -; mRNA CCDS; CCDS4561.1; - RefSeq; NP_008929.2; NM_006998.3 UniGene; Hs.116428; - ProteinModelPortal; O76038; - SMR; O76038; - BioGrid; 115839; 22 IntAct; O76038; 2 STRING; 9606.ENSP00000367197; - iPTMnet; O76038; - PhosphoSitePlus; O76038; - SwissPalm; O76038; - BioMuta; SCGN; - MaxQB; O76038; - PaxDb; O76038; - PeptideAtlas; O76038; - PRIDE; O76038; - ProteomicsDB; 50358; - Ensembl; ENST00000377961; ENSP00000367197; ENSG00000079689 GeneID; 10590; - KEGG; hsa:10590; - UCSC; uc003nfb.4; human CTD; 10590; - DisGeNET; 10590; - EuPathDB; HostDB:ENSG00000079689.13; - GeneCards; SCGN; - HGNC; HGNC:16941; SCGN HPA; CAB004005; - HPA; CAB044060; - HPA; CAB062563; - HPA; CAB068232; - HPA; HPA006641; - MIM; 609202; gene neXtProt; NX_O76038; - OpenTargets; ENSG00000079689; - PharmGKB; PA38428; - eggNOG; KOG0027; Eukaryota eggNOG; COG5126; LUCA GeneTree; ENSGT00390000013118; - HOGENOM; HOG000231866; - HOVERGEN; HBG000855; - InParanoid; O76038; - OMA; HHKKAIS; - OrthoDB; EOG091G0GNH; - PhylomeDB; O76038; - TreeFam; TF325083; - ChiTaRS; SCGN; human GeneWiki; SCGN; - GenomeRNAi; 10590; - PRO; PR:O76038; - Proteomes; UP000005640; Chromosome 6 Bgee; ENSG00000079689; - CleanEx; HS_SCGN; - ExpressionAtlas; O76038; baseline and differential Genevisible; O76038; HS GO; GO:0005737; C:cytoplasm; NAS:UniProtKB GO; GO:0005829; C:cytosol; IBA:GO_Central GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell GO; GO:0043005; C:neuron projection; IBA:GO_Central GO; GO:0005634; C:nucleus; IBA:GO_Central GO; GO:0045202; C:synapse; IBA:GO_Central GO; GO:0030658; C:transport vesicle membrane; IEA:UniProtKB-SubCell GO; GO:0005509; F:calcium ion binding; IBA:GO_Central GO; GO:0051480; P:regulation of cytosolic calcium ion concentration; IBA:GO_Central CDD; cd16178; EFh_HEF_SCGN; 1 InterPro; IPR011992; EF-hand-dom_pair InterPro; IPR018247; EF_Hand_1_Ca_BS InterPro; IPR002048; EF_hand_dom InterPro; IPR035798; EFh_SCGN Pfam; PF13202; EF-hand_5; 1 Pfam; PF13499; EF-hand_7; 1 SMART; SM00054; EFh; 5 SUPFAM; SSF47473; SSF47473; 2 PROSITE; PS00018; EF_HAND_1; 4 PROSITE; PS50222; EF_HAND_2; 6 2: Evidence at transcript level; Calcium; Complete proteome; Cytoplasm; Cytoplasmic vesicle; Membrane; Metal-binding; Polymorphism; Reference proteome; Repeat; Secreted CHAIN 1 276 Secretagogin /FTId=PRO_0000073636 DOMAIN 12 47 EF-hand 1. {ECO:0000255|PROSITE- ProRule:PRU00448} DOMAIN 58 93 EF-hand 2. {ECO:0000255|PROSITE- ProRule:PRU00448} DOMAIN 105 140 EF-hand 3. {ECO:0000255|PROSITE- ProRule:PRU00448} DOMAIN 149 184 EF-hand 4. {ECO:0000255|PROSITE- ProRule:PRU00448} DOMAIN 197 232 EF-hand 5. {ECO:0000255|PROSITE- ProRule:PRU00448} DOMAIN 240 276 EF-hand 6. {ECO:0000255|PROSITE- ProRule:PRU00448} CA_BIND 25 36 1. {ECO:0000255|PROSITE- ProRule:PRU00448} CA_BIND 71 82 2. {ECO:0000255|PROSITE- ProRule:PRU00448} CA_BIND 118 129 3. {ECO:0000255|PROSITE- ProRule:PRU00448} CA_BIND 162 173 4. {ECO:0000255|PROSITE- ProRule:PRU00448} CA_BIND 210 221 5. {ECO:0000255|PROSITE- ProRule:PRU00448} CA_BIND 254 265 6. {ECO:0000255|PROSITE- ProRule:PRU00448} VARIANT 216 216 A -> V (in dbSNP:rs6942245) /FTId=VAR_042710 CONFLICT 22 22 Q -> R (in Ref. 1; CAA76365) SEQUENCE 276 AA; 32040 MW; EB970BF7B8763F33 CRC64; MDSSREPTLG RLDAAGFWQV WQRFDADEKG YIEEKELDAF FLHMLMKLGT DDTVMKANLH KVKQQFMTTQ DASKDGRIRM KELAGMFLSE DENFLLLFRR ENPLDSSVEF MQIWRKYDAD SSGFISAAEL RNFLRDLFLH HKKAISEAKL EEYTGTMMKI FDRNKDGRLD LNDLARILAL QENFLLQFKM DACSTEERKR DFEKIFAYYD VSKTGALEGP EVDGFVKDMM ELVQPSISGV DLDKFREILL RHCDVNKDGK IQKSELALCL GLKINP
Research Areas
Citations (0)

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Background

SCGN is a secreted calcium-binding protein which is found in the cytoplasm. It is related to calbindin D-28K and calretinin. SCGN is thought to be involved in KCL-stimulated calcium flux and cell proliferation.

References

Skovhus,K.V., Scand. J. Immunol. 64 (6), 639-645 (2006)Zierhut,B., Biochem. Biophys. Res. Commun. 329 (4), 1193-1199 (2005)Mungall,A.J., Nature 425 (6960), 805-811 (2003)Zhan,X., Pituitary 6 (4), 189-202 (2003)

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Cat# BP1458a
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