|Other Names||P2Y purinoceptor 1, P2Y1, ATP receptor, Purinergic receptor, P2RY1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for extracellular adenine nucleotides such as ADP (PubMed:9442040, PubMed:9038354, PubMed:25822790). In platelets, binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and ultimately platelet aggregation (PubMed:9442040).|
|Cellular Location||Cell membrane; Multi-pass membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
The product of this gene belongs to the family ofG-protein coupled receptors. This family has several receptorsubtypes with different pharmacological selectivity, which overlapsin some cases, for various adenosine and uridine nucleotides. Thisreceptor functions as a receptor for extracellular ATP and ADP. Inplatelets binding to ADP leads to mobilization of intracellularcalcium ions via activation of phospholipase C, a change inplatelet shape, and probably to platelet aggregation. [provided byRefSeq].
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Maloney, S.F., et al. Integr Biol (Camb) 2(4):183-192(2010)Nisar, S., et al. Traffic 11(4):508-519(2010)Kumar, T.S., et al. J. Med. Chem. 53(6):2562-2576(2010)Bambace, N.M., et al. Platelets 21(2):85-93(2010)
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