|Other Names||Protein Wnt-3a, WNT3A|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Ligand for members of the frizzled family of seven transmembrane receptors. Wnt-3 and Wnt-3a play distinct roles in cell-cell signaling during morphogenesis of the developing neural tube.|
|Cellular Location||Secreted, extracellular space, extracellular matrix|
|Tissue Location||Moderately expressed in placenta and at low levels in adult lung, spleen, and prostate|
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The WNT gene family consists of structurally related geneswhich encode secreted signaling proteins. These proteins have beenimplicated in oncogenesis and in several developmental processes,including regulation of cell fate and patterning duringembryogenesis. This gene is a member of the WNT gene family. Itencodes a protein which shows 96% amino acid identity to mouseWnt3A protein, and 84% to human WNT3 protein, another WNT geneproduct. This gene is clustered with WNT14 gene, another familymember, in chromosome 1q42 region.
Sengupta, P.K., et al. J. Biol. Chem. 285(41):31164-31173(2010)Hubner, R., et al. Biochem. Biophys. Res. Commun. 400(3):358-362(2010)von Marschall, Z., et al. Biochem. Biophys. Res. Commun. 400(3):299-304(2010)Shin, H., et al. J. Dermatol. Sci. 58(2):91-96(2010)Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :
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