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WNT3A Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P56704 |
|---|---|
| Clone Names | 100507254 |
| Gene ID | 89780 |
|---|---|
| Other Names | Protein Wnt-3a, WNT3A |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | WNT3A |
|---|---|
| Function | Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (PubMed:20093360, PubMed:21244856, PubMed:24841207, PubMed:26902720). Required for normal embryonic mesoderm development and formation of caudal somites. Required for normal morphogenesis of the developing neural tube (By similarity). Mediates self-renewal of the stem cells at the bottom on intestinal crypts (in vitro) (PubMed:26902720). |
| Cellular Location | Secreted, extracellular space, extracellular matrix {ECO:0000250|UniProtKB:P27467}. Secreted |
| Tissue Location | Moderately expressed in placenta and at low levels in adult lung, spleen, and prostate. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
The WNT gene family consists of structurally related geneswhich encode secreted signaling proteins. These proteins have beenimplicated in oncogenesis and in several developmental processes,including regulation of cell fate and patterning duringembryogenesis. This gene is a member of the WNT gene family. Itencodes a protein which shows 96% amino acid identity to mouseWnt3A protein, and 84% to human WNT3 protein, another WNT geneproduct. This gene is clustered with WNT14 gene, another familymember, in chromosome 1q42 region.
References
Sengupta, P.K., et al. J. Biol. Chem. 285(41):31164-31173(2010)Hubner, R., et al. Biochem. Biophys. Res. Commun. 400(3):358-362(2010)von Marschall, Z., et al. Biochem. Biophys. Res. Commun. 400(3):299-304(2010)Shin, H., et al. J. Dermatol. Sci. 58(2):91-96(2010)Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :
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