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E2F3 Antibody (Center) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession O00716
Clone Names 100507256
Peptide ID 100507256
Additional Information
Gene ID 1871
Other Names Transcription factor E2F3, E2F-3, E2F3, KIAA0075
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name E2F3
Synonyms KIAA0075
Function Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC- 3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F3 binds specifically to RB1 in a cell-cycle dependent manner. Inhibits adipogenesis, probably through the repression of CEBPA binding to its target gene promoters (By similarity).
Cellular Location Nucleus.
Research Areas
Citations (0)

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The protein encoded by this gene is a member of the E2Ffamily of transcription factors. The E2F family plays a crucialrole in the control of cell cycle and action of tumor suppressorproteins and is also a target of the transforming proteins of smallDNA tumor viruses. The E2F proteins contain several evolutionallyconserved domains found in most members of the family. Thesedomains include a DNA binding domain, a dimerization domain whichdetermines interaction with the differentiation regulatedtranscription factor proteins (DP), a transactivation domainenriched in acidic amino acids, and a tumor suppressor proteinassociation domain which is embedded within the transactivationdomain. This protein and another 2 members, E2F1 and E2F2, have anadditional cyclin binding domain. This protein binds specificallyto retinoblastoma protein pRB in a cell-cycle dependent manner.


Revenko, A.S., et al. Mol. Cell. Biol. 30(22):5260-5272(2010)Biswas, S., et al. Proc. Natl. Acad. Sci. U.S.A. 107(15):6976-6981(2010)Martinez, L.A., et al. Mol. Cell. Biol. 30(2):524-536(2010)Cunningham, J.M., et al. Br. J. Cancer 101(8):1461-1468(2009)Madhavan, J., et al. Mol. Vis. 15, 235-240 (2009) :

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$ 80.00
Cat# BP14598c
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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