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Mouse Aak1 Antibody (Center) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q3UHJ0
Clone Names 110316021
Peptide ID 110316021
Additional Information
Gene ID 269774
Other Names AP2-associated protein kinase 1, Adaptor-associated kinase 1, Aak1, Kiaa1048
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name Aak1
Synonyms Kiaa1048
Function Regulates clathrin-mediated endocytosis by phosphorylating the AP2M1/mu2 subunit of the adaptor protein complex 2 (AP-2) which ensures high affinity binding of AP-2 to cargo membrane proteins during the initial stages of endocytosis. Isoform 1 and isoform 2 display similar levels of kinase activity towards AP2M1. Regulates phosphorylation of other AP-2 subunits as well as AP-2 localization and AP-2-mediated internalization of ligand complexes. Phosphorylates NUMB and regulates its cellular localization, promoting NUMB localization to endosomes. Binds to and stabilizes the activated form of NOTCH1, increases its localization in endosomes and regulates its transcriptional activity (By similarity).
Cellular Location Cell membrane; Peripheral membrane protein. Membrane, clathrin-coated pit. Note=Active when found in clathrin-coated pits at the plasma membrane. In neuronal cells, enriched at presynaptic terminals. In non-neuronal cells, enriched at leading edge of migrating cells (By similarity).
Research Areas
Citations (0)

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Aak1 phosphorylates the AP2M1/mu2 subunit of the adaptor protein complex 2 (AP-2). May play a role in regulating aspects of clathrin-mediated endocytosis (By similarity).


Munton, R.P., et al. Mol. Cell Proteomics 6(2):283-293(2007)Nishimura, M., et al. DNA Res. 11(5):315-323(2004)Jha, A., et al. J. Biol. Chem. 279(3):2281-2290(2004)Zambrowicz, B.P., et al. Proc. Natl. Acad. Sci. U.S.A. 100(24):14109-14114(2003)Hansen, J., et al. Proc. Natl. Acad. Sci. U.S.A. 100(17):9918-9922(2003)

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$ 80.00
Cat# BP14604c
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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