Mouse Acvr1c Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q8K348 |
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Clone Names | 110316027 |
Gene ID | 269275 |
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Other Names | Activin receptor type-1C, Activin receptor type IC, ACTR-IC, Activin receptor-like kinase 7, ALK-7, Acvr1c {ECO:0000312|EMBL:AAH287801} |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | Acvr1c {ECO:0000312|EMBL:AAH28780.1} |
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Function | Serine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B and NODAL. Plays a role in cell differentiation, growth arrest and apoptosis. |
Cellular Location | Membrane; Single-pass type I membrane protein |
Tissue Location | Expressed in interdigital regions in developing limb buds. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Serine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B and NODAL. Plays a role in cell differentiation, growth arrest and apoptosis.
References
Andersson, O., et al. Proc. Natl. Acad. Sci. U.S.A. 105(20):7252-7256(2008)Bertolino, P., et al. Proc. Natl. Acad. Sci. U.S.A. 105(20):7246-7251(2008)Liguori, G.L., et al. Dev. Biol. 315(2):280-289(2008)Kurrasch, D.M., et al. J. Neurosci. 27(50):13624-13634(2007)Kogame, M., et al. J. Med. Invest. 53 (3-4), 238-245 (2006) :
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