|Other Names||Acyl-coenzyme A thioesterase 13, Acyl-CoA thioesterase 13, 312-, Thioesterase superfamily member 2, Acyl-coenzyme A thioesterase 13, N-terminally processed, ACOT13, THEM2|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP1460a was selected from the N-term region of human THEM2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Has acyl-CoA thioesterase activity towards medium (C12) and long-chain (C18) fatty acyl-CoA substrates. Can also hydrolyze 3- hydroxyphenylacetyl-CoA and 3,4-dihydroxyphenylacetyl-CoA (in vitro). May play a role in controlling adaptive thermogenesis (By similarity).|
|Cellular Location||Cytoplasm, cytosol. Mitochondrion. Nucleus. Cytoplasm, cytoskeleton, spindle. Note=During interphase, found both in the nucleus and in the cytoplasm. At mitosis, localizes to the spindle. Colocalizes with tubulin (By similarity)|
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Provided below are standard protocols that you may find useful for product applications.
Human thioesterase superfamily member 2 (hTHEM2) belongs to the hotdog-fold enzyme superfamily. The encoding gene is highly expressed in the kidney, and moderately expressed in the liver, brain, large intestine, and small intestine. THEM2 is essential for cell sustained proliferation based on small interference RNA silencing studies. THEM2 co-localizes with microtubules in immunostaining and GFP-Tag experiments.
Cheng,Z., Biochem. Biophys. Res. Commun. 350 (4), 850-853 (2006)Cheng,Z., Biochem. Biophys. Res. Commun. 349 (1), 172-177 (2006)
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