|Other Names||Dual specificity protein kinase CLK4, CDC-like kinase 4, Clk4|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex and may be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates SRSF1 and SRSF3. Required for the regulation of alternative splicing of MAPT/TAU. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells.|
|Tissue Location||Expressed in the hippocampus, the cerebellum and the olfactory bulb.|
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Phosphorylates serine-and arginine-rich (SR) proteins of the spliceosomal complex may be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates serines, threonines and tyrosines. Required for the regulation of alternative splicing of MAPT/TAU.
Katsu, R., et al. J. Biol. Chem. 277(46):44220-44228(2002)Hartmann, A.M., et al. Mol. Cell. Neurosci. 18(1):80-90(2001)Watkins-Chow, D.E., et al. Genomics 45(1):147-157(1997)Nayler, O., et al. Biochem. J. 326 (PT 3), 693-700 (1997) :
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