|Other Names||Dual specificity tyrosine-phosphorylation-regulated kinase 1B, Dyrk1b|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activity. Enhances the transcriptional activity of TCF1/HNF1A and FOXO1. Inhibits epithelial cell migration. Mediates colon carcinoma cell survival in mitogen-poor environments. Inhibits the SHH and WNT1 pathways, thereby enhancing adipogenesis. In addition, promotes expression of the gluconeogenic enzyme glucose-6-phosphatase (G6PC).|
|Tissue Location||Isoform 1 and isoform 2 are broadly expressed. Isoform 3 seems specific for skeletal muscle (at protein level)|
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Dual-specificity kinase which possesses both serine/ threonine and tyrosine kinase activity. Enhances the transcriptional activity of TCF1/HNF1A and FOXO1. Inhibits epithelial cell migration. Mediates colon carcinoma cell survival in mitogen-poor environments.
Janumyan, Y., et al. J. Biol. Chem. 283(49):34108-34120(2008)Munton, R.P., et al. Mol. Cell Proteomics 6(2):283-293(2007)Mercer, S.E., et al. J. Biol. Chem. 280(27):25788-25801(2005)Collins, M.O., et al. J. Biol. Chem. 280(7):5972-5982(2005)Deng, X., et al. J. Biol. Chem. 280(6):4894-4905(2005)
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