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Mouse Ntrk3 Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q6VNS1 |
|---|---|
| Clone Names | 110316304 |
| Gene ID | 18213 |
|---|---|
| Other Names | NT-3 growth factor receptor, GP145-TrkC, Trk-C, Neurotrophic tyrosine kinase receptor type 3, TrkC tyrosine kinase, Ntrk3, TrkC |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | Ntrk3 |
|---|---|
| Synonyms | TrkC |
| Function | Receptor tyrosine kinase involved in nervous system and probably heart development. Upon binding of its ligand NTF3/neurotrophin-3, NTRK3 autophosphorylates and activates different signaling pathways, including the phosphatidylinositol 3-kinase/AKT and the MAPK pathways, that control cell survival and differentiation. |
| Cellular Location | Membrane; Single-pass type I membrane protein |
| Tissue Location | Isoform 2 expression is restricted to specific areas in adult brain. Isoform 3 transcripts are readily detected early during embryogenesis and are expressed predominantly in adult brain and gonads. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Ntrk3 is a receptor for neurotrophin-3 (NT-3). This is a tyrosine-protein kinase receptor. Known substrates for the Trk receptors are SHC1, PI 3-kinase, and PLC-gamma-1 (By similarity).
References
Gascon, E., et al. J. Neurosci. 30(37):12414-12423(2010)Nikoletopoulou, V., et al. Nature 467(7311):59-63(2010)Honma, Y., et al. Development 137(14):2319-2328(2010)Huang, T., et al. J Mol Cell Biol 2(3):152-163(2010)Li, W., et al. BMC Biol. 8, 86 (2010) :
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