|Other Names||Serine/threonine-protein kinase 10, Lymphocyte-oriented kinase, Stk10, Lok|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Serine/threonine-protein kinase involved in regulation of lymphocyte migration. Phosphorylates MSN, and possibly PLK1. Involved in regulation of lymphocyte migration by mediating phosphorylation of ERM proteins such as MSN. Acts as a negative regulator of MAP3K1/MEKK1. May also act as a cell cycle regulator by acting as a polo kinase kinase: mediates phosphorylation of PLK1 in vitro; however such data require additional evidences in vivo.|
|Cellular Location||Cell membrane; Peripheral membrane protein|
|Tissue Location||Expressed predominantly in lymphoid organs such as spleen, thymus, and bone marrow|
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Provided below are standard protocols that you may find useful for product applications.
Stk10 can act on substrates such as myelin basic protein and histone 2A on serine and threonine residues.
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