|Other Names||Nucleolin, Protein C23, NCL|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process of transcriptional elongation. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats.|
|Cellular Location||Nucleus, nucleolus. Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs|
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Nucleolin (NCL), a eukaryotic nucleolar phosphoprotein, isinvolved in the synthesis and maturation of ribosomes. It islocated mainly in dense fibrillar regions of the nucleolus. HumanNCL gene consists of 14 exons with 13 introns and spansapproximately 11kb. The intron 11 of the NCL gene encodes a smallnucleolar RNA, termed U20.
Ishimaru, D., et al. J. Biol. Chem. 285(35):27182-27191(2010)Tulchin, N., et al. Am. J. Pathol. 176(3):1203-1214(2010)Strang, B.L., et al. J. Virol. 84(4):1771-1784(2010)Bertrand, L., et al. J. Virol. 84(1):109-118(2010)Jerke, U., et al. PLoS ONE 4 (12), E8302 (2009) :
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