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PLCD3 Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q8N3E9 |
|---|---|
| Clone Names | 100318207 |
| Gene ID | 113026 |
|---|---|
| Other Names | 1-phosphatidylinositol 4, 5-bisphosphate phosphodiesterase delta-3, Phosphoinositide phospholipase C-delta-3, Phospholipase C-delta-3, PLC-delta-3, PLCD3, KIAA1964 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | PLCD3 (HGNC:9061) |
|---|---|
| Synonyms | KIAA1964 |
| Function | Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Essential for trophoblast and placental development. May participate in cytokinesis by hydrolyzing PIP2 at the cleavage furrow (PubMed:10336610). Regulates neurite outgrowth through the inhibition of RhoA/Rho kinase signaling (By similarity). |
| Cellular Location | Membrane; Peripheral membrane protein. Cytoplasm. Cleavage furrow. Note=Localizes at the cleavage furrow during cytokinesis. |
| Tissue Location | Present in corneal epithelial cells (at protein level). |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a member of the phospholipase C family,which catalyze the hydrolysis of phosphatidylinositol4,5-bisphosphate to generate the second messengers diacylglyceroland inositol 1,4,5-trisphosphate (IP3). Diacylglycerol and IP3mediate a variety of cellular responses to extracellular stimuli byinducing protein kinase C and increasing cytosolic Ca(2+)concentrations. This enzyme localizes to the plasma membrane andrequires calcium for activation. Its activity is inhibited byspermine, sphingosine, and several phospholipids. [provided byRefSeq].
References
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Segat, L., et al. Vaccine 28(10):2201-2206(2010)Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Newton-Cheh, C., et al. Nat. Genet. 41(6):666-676(2009)Rebecchi, M.J., et al. Adv. Enzyme Regul. 49(1):59-73(2009)
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