|Other Names||Low-density lipoprotein receptor-related protein 5, LRP-5, LRP5, LR3, LRP7|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor- ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. Plays a role in norrin (NDP) signal transduction (PubMed:27228167). The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta- catenin. Appears be required for postnatal control of vascular regression in the eye (By similarity). Required for posterior patterning of the epiblast during gastrulation (By similarity).|
|Cellular Location||Membrane; Single-pass type I membrane protein. Endoplasmic reticulum. Note=Chaperoned to the plasma membrane by MESD.|
|Tissue Location||Widely expressed, with the highest level of expression in the liver and in aorta|
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This gene encodes a transmembrane low-density lipoproteinreceptor that binds and internalizes ligands in the process ofreceptor-mediated endocytosis. This protein also acts as aco-receptor with Frizzled protein family members for transducingsignals by Wnt proteins and was originally cloned on the basis ofits association with type 1 diabetes mellitus in humans. Thisprotein plays a key role in skeletal homeostasis and many bonedensity related diseases are caused by mutations in this gene.Mutations in this gene also cause familial exudativevitreoretinopathy.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Lee, D.Y., et al. Menopause 17(5):1064-1070(2010)Liu, J.M., et al. J. Clin. Endocrinol. Metab. 95 (9), E112-E120 (2010) :Paternoster, L., et al. J. Clin. Endocrinol. Metab. 95(8):3940-3948(2010)Stathopoulou, M.G., et al. J Am Diet Assoc 110(7):1078-1083(2010)
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