|Other Names||Interleukin-25, IL-25, Interleukin-17E, IL-17E, IL25, IL17E|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Induces activation of NF-kappa-B and stimulates production of the proinflammatory chemokine IL-8. Proinflammatory cytokine favoring Th2-type immune responses.|
|Tissue Location||Expressed at low levels in several tissues, including brain, kidney, lung, prostate, testis, spinal cord, adrenal gland, and trachea|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a cytokine that sharessequence similarity with interleukin 17. This cytokine can induceNF-kappaB activation, and stimulate the production of interleukin8. Both this cytokine and interleukin 17B are ligands for thecytokine receptor IL17BR. Studies of a similar gene in mice suggestthat this cytokine may be a pro-inflammatory cytokine favoring theTh2-type immune response. Alternative splicing results in multipletranscript variants.
Xu, G., et al. Allergy 65(5):581-589(2010)Davila, S., et al. Genes Immun. 11(3):232-238(2010)Goswami, S., et al. Nat. Immunol. 10(5):496-503(2009)Caruso, R., et al. Blood 113(15):3512-3519(2009)Garley, M., et al. Adv Med Sci 53(2):326-330(2008)
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