IL25 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q9H293 |
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Clone Names | 100517118 |
Gene ID | 64806 |
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Other Names | Interleukin-25, IL-25, Interleukin-17E, IL-17E, IL25, IL17E |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | IL25 |
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Synonyms | IL17E |
Function | Cytokine produced by various cells such as eosinophils, T- helper type 2 (Th2) cells or epithelial cells that plays a role in internal safety of adaptive immune responses by regulating cytokine production (PubMed:25821217, PubMed:15860795). Promotes and augments T- helper type 2 responses locally or systemically (PubMed:25821217). Exerts its activity via its receptor composed of IL17RA and IL17RB for signal transduction (By similarity). In turn, stimulates the JAK2- STAT5A pathway and promotes the secretion of type-2 associated cytokines including IL4, IL9 and IL13 (PubMed:25821217). Induces also the release of IL8, and IL6 from eosinophils through the combined activation of MAPK and NF-kappa-B pathways (PubMed:15860795). Inhibits the differentiation of T-helper (Th17) cells via the production of IL4, IL5 and IL13 (PubMed:11754819). |
Cellular Location | Secreted. |
Tissue Location | Expressed at low levels in several tissues, including brain, kidney, lung, prostate, testis, spinal cord, adrenal gland, and trachea |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is a cytokine that sharessequence similarity with interleukin 17. This cytokine can induceNF-kappaB activation, and stimulate the production of interleukin8. Both this cytokine and interleukin 17B are ligands for thecytokine receptor IL17BR. Studies of a similar gene in mice suggestthat this cytokine may be a pro-inflammatory cytokine favoring theTh2-type immune response. Alternative splicing results in multipletranscript variants.
References
Xu, G., et al. Allergy 65(5):581-589(2010)Davila, S., et al. Genes Immun. 11(3):232-238(2010)Goswami, S., et al. Nat. Immunol. 10(5):496-503(2009)Caruso, R., et al. Blood 113(15):3512-3519(2009)Garley, M., et al. Adv Med Sci 53(2):326-330(2008)
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