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IL25 Antibody (Center) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q9H293
Clone Names 100517118
Additional Information
Gene ID 64806
Other Names Interleukin-25, IL-25, Interleukin-17E, IL-17E, IL25, IL17E
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name IL25
Synonyms IL17E
Function Cytokine produced by various cells such as eosinophils, T- helper type 2 (Th2) cells or epithelial cells that plays a role in internal safety of adaptive immune responses by regulating cytokine production (PubMed:25821217, PubMed:15860795). Promotes and augments T- helper type 2 responses locally or systemically (PubMed:25821217). Exerts its activity via its receptor composed of IL17RA and IL17RB for signal transduction (By similarity). In turn, stimulates the JAK2- STAT5A pathway and promotes the secretion of type-2 associated cytokines including IL4, IL9 and IL13 (PubMed:25821217). Induces also the release of IL8, and IL6 from eosinophils through the combined activation of MAPK and NF-kappa-B pathways (PubMed:15860795). Inhibits the differentiation of T-helper (Th17) cells via the production of IL4, IL5 and IL13 (PubMed:11754819).
Cellular Location Secreted.
Tissue Location Expressed at low levels in several tissues, including brain, kidney, lung, prostate, testis, spinal cord, adrenal gland, and trachea
Research Areas
Citations (0)
citation

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Background

The protein encoded by this gene is a cytokine that sharessequence similarity with interleukin 17. This cytokine can induceNF-kappaB activation, and stimulate the production of interleukin8. Both this cytokine and interleukin 17B are ligands for thecytokine receptor IL17BR. Studies of a similar gene in mice suggestthat this cytokine may be a pro-inflammatory cytokine favoring theTh2-type immune response. Alternative splicing results in multipletranscript variants.

References

Xu, G., et al. Allergy 65(5):581-589(2010)Davila, S., et al. Genes Immun. 11(3):232-238(2010)Goswami, S., et al. Nat. Immunol. 10(5):496-503(2009)Caruso, R., et al. Blood 113(15):3512-3519(2009)Garley, M., et al. Adv Med Sci 53(2):326-330(2008)

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$ 277.78
Cat# BP14661c
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