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CPT1A Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P50416 |
|---|---|
| Clone Names | 100525054 |
| Gene ID | 1374 |
|---|---|
| Other Names | Carnitine O-palmitoyltransferase 1, liver isoform, CPT1-L, Carnitine O-palmitoyltransferase I, liver isoform, CPT I, CPTI-L, Carnitine palmitoyltransferase 1A, CPT1A, CPT1 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | CPT1A (HGNC:2328) |
|---|---|
| Synonyms | CPT1 |
| Function | Catalyzes the transfer of the acyl group of long-chain fatty acid-CoA conjugates onto carnitine, an essential step for the mitochondrial uptake of long-chain fatty acids and their subsequent beta-oxidation in the mitochondrion (PubMed:9691089, PubMed:11350182, PubMed:14517221, PubMed:16651524). Plays an important role in hepatic triglyceride metabolism (By similarity). |
| Cellular Location | Mitochondrion outer membrane; Multi-pass membrane protein |
| Tissue Location | Strong expression in kidney and heart, and lower in liver and skeletal muscle |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
The mitochondrial oxidation of long-chain fatty acids isinitiated by the sequential action of carnitinepalmitoyltransferase I (which is located in the outer membrane andis detergent-labile) and carnitine palmitoyltransferase II (whichis located in the inner membrane and is detergent-stable), togetherwith a carnitine-acylcarnitine translocase. CPT I is the key enzymein the carnitine-dependent transport across the mitochondrial innermembrane and its deficiency results in a decreased rate of fattyacid beta-oxidation. Alternatively spliced transcript variantsencoding different isoforms have been found for this gene.
References
Gessner, B.D., et al. Pediatrics 126(5):945-951(2010)Collins, S.A., et al. Mol. Genet. Metab. 101 (2-3), 200-204 (2010) :Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Song, S., et al. Mol. Cell. Endocrinol. 325 (1-2), 54-63 (2010) :Ruano, G., et al. Pharmacogenomics 11(7):959-971(2010)
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