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RUNX3 Antibody (Center) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q13761
Clone Names 100525094
Peptide ID 100525094
Additional Information
Gene ID 864
Other Names Runt-related transcription factor 3, Acute myeloid leukemia 2 protein, Core-binding factor subunit alpha-3, CBF-alpha-3, Oncogene AML-2, Polyomavirus enhancer-binding protein 2 alpha C subunit, PEA2-alpha C, PEBP2-alpha C, SL3-3 enhancer factor 1 alpha C subunit, SL3/AKV core-binding factor alpha C subunit, RUNX3, AML2, CBFA3, PEBP2A3
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name RUNX3
Synonyms AML2, CBFA3, PEBP2A3
Function Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA- binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. The heterodimers bind to the core site of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL3 and GM-CSF promoters (By similarity). May be involved in the control of cellular proliferation and/or differentiation. In association with ZFHX3, upregulates CDKN1A promoter activity following TGF-beta stimulation (PubMed:20599712). CBF complexes repress ZBTB7B transcription factor during cytotoxic (CD8+) T cell development. They bind to RUNX-binding sequence within the ZBTB7B locus acting as transcriptional silencer and allowing for cytotoxic T cell differentiation. CBF complexes binding to the transcriptional silencer is essential for recruitment of nuclear protein complexes that catalyze epigenetic modifications to establish epigenetic ZBTB7B silencing (By similarity).
Cellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00399, ECO:0000269|PubMed:20100835, ECO:0000269|PubMed:20599712}. Cytoplasm Note=The tyrosine phosphorylated form localizes to the cytoplasm Translocates from the cytoplasm to the nucleus following TGF-beta stimulation.
Tissue Location Expressed in gastric cancer tissues (at protein level).
Research Areas
Citations (0)

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Background

This gene encodes a member of the runt domain-containingfamily of transcription factors. A heterodimer of this protein anda beta subunit forms a complex that binds to the core DNA sequence5'-PYGPYGGT-3' found in a number of enhancers and promoters, andcan either activate or suppress transcription. It also interactswith other transcription factors. It functions as a tumorsuppressor, and the gene is frequently deleted or transcriptionallysilenced in cancer. Multiple transcript variants encoding differentisoforms have been found for this gene.

References

Tsang, Y.H., et al. Oncogene 29(41):5643-5650(2010)Shimada, M., et al. Hum. Genet. 128(4):433-441(2010)Iwatani, K., et al. Biochem. Biophys. Res. Commun. 400(3):426-431(2010)Kodach, L.L., et al. Carcinogenesis 31(9):1567-1575(2010)Nishio, M., et al. Anticancer Res. 30(7):2673-2682(2010)

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$ 80.00
Cat# BP14667c
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