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RUNX3 Antibody (Center) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q13761
Clone Names 100525094
Peptide ID 100525094
Additional Information
Gene ID 864
Other Names Runt-related transcription factor 3, Acute myeloid leukemia 2 protein, Core-binding factor subunit alpha-3, CBF-alpha-3, Oncogene AML-2, Polyomavirus enhancer-binding protein 2 alpha C subunit, PEA2-alpha C, PEBP2-alpha C, SL3-3 enhancer factor 1 alpha C subunit, SL3/AKV core-binding factor alpha C subunit, RUNX3, AML2, CBFA3, PEBP2A3
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name RUNX3
Synonyms AML2, CBFA3, PEBP2A3
Function CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, lck, IL-3 and GM-CSF promoters.
Cellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00399, ECO:0000269|PubMed:20100835}. Cytoplasm. Note=The tyrosine phosphorylated form localizes to the cytoplasm
Research Areas
Citations (0)

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This gene encodes a member of the runt domain-containingfamily of transcription factors. A heterodimer of this protein anda beta subunit forms a complex that binds to the core DNA sequence5'-PYGPYGGT-3' found in a number of enhancers and promoters, andcan either activate or suppress transcription. It also interactswith other transcription factors. It functions as a tumorsuppressor, and the gene is frequently deleted or transcriptionallysilenced in cancer. Multiple transcript variants encoding differentisoforms have been found for this gene.


Tsang, Y.H., et al. Oncogene 29(41):5643-5650(2010)Shimada, M., et al. Hum. Genet. 128(4):433-441(2010)Iwatani, K., et al. Biochem. Biophys. Res. Commun. 400(3):426-431(2010)Kodach, L.L., et al. Carcinogenesis 31(9):1567-1575(2010)Nishio, M., et al. Anticancer Res. 30(7):2673-2682(2010)

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$ 80.00
Cat# BP14667c
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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