|Other Names||Phospholipase D2, PLD 2, hPLD2, Choline phosphatase 2, PLD1C, Phosphatidylcholine-hydrolyzing phospholipase D2, PLD2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May have a role in signal-induced cytoskeletal regulation and/or endocytosis.|
|Cellular Location||Membrane; Peripheral membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
Phosphatidylcholine (PC)-specific phospholipases D (PLDs;EC 22.214.171.124) catalyze the hydrolysis of PC to produce phosphatidicacid and choline. Activation of PC-specific PLDs occurs as aconsequence of agonist stimulation of both tyrosine kinase and Gprotein-coupled receptors. PC-specific PLDs have been proposed tofunction in regulated secretion, cytoskeletal reorganization,transcriptional regulation, and cell cycle control.[supplied byOMIM].
Chae, Y.C., et al. Mol. Cell. Biol. 30(21):5086-5098(2010)Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Knapek, K., et al. Mol. Cell. Biol. 30(18):4492-4506(2010)Tabatabaian, F., et al. J. Biol. Chem. 285(25):18991-19001(2010)Kang, D.W., et al. PLoS ONE 5 (8), E12109 (2010) :
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