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PLAA Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9Y263 |
|---|---|
| Clone Names | 70319154 |
| Gene ID | 9373 |
|---|---|
| Other Names | Phospholipase A-2-activating protein, PLA2P, PLAP, PLAA, PLAP |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP1466b was selected from the C-term region of human PLAA. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | PLAA |
|---|---|
| Synonyms | PLAP |
| Function | Plays a role in protein ubiquitination, sorting and degradation through its association with VCP (PubMed:27753622). Involved in ubiquitin-mediated membrane proteins trafficking to late endosomes in an ESCRT-dependent manner, and hence plays a role in synaptic vesicle recycling (By similarity). May play a role in macroautophagy, regulating for instance the clearance of damaged lysosomes (PubMed:27753622). Plays a role in cerebellar Purkinje cell development (By similarity). Positively regulates cytosolic and calcium-independent phospholipase A2 activities in a tumor necrosis factor alpha (TNF-alpha)- or lipopolysaccharide (LPS)-dependent manner, and hence prostaglandin E2 biosynthesis (PubMed:18291623, PubMed:28007986). |
| Cellular Location | Nucleus. Cytoplasm. Synapse {ECO:0000250|UniProtKB:P27612}. Note=Recruited to damaged lysosomes decorated with K48-linked ubiquitin chains |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
PLAA stimulates human neutrophil aggregation and release of lysosomal enzymes, superoxide, and eicosanoids. It plays an important role in the regulation of specific inflammatory processes connected to such diseases as inflammatory bowel disease, pancreatitis, rheumatoid arthritis, and cutaneous malignant melanoma.
References
Koumanov,K., Cell Biol. Int. 27 (10), 871-877 (2003)Kozlenkov,A., J. Biol. Chem. 277 (25), 22992-22999 (2002)Beatty,B.G., Genomics 62 (3), 529-532 (1999)
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