|Other Names||Fibulin-1, FIBL-1, FBLN1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes. Has been implicated in a role in cellular transformation and tumor invasion, it appears to be a tumor suppressor. May play a role in haemostasis and thrombosis owing to its ability to bind fibrinogen and incorporate into clots. Could play a significant role in modulating the neurotrophic activities of APP, particularly soluble APP.|
|Cellular Location||Secreted, extracellular space, extracellular matrix|
|Tissue Location||Isoform A and isoform B are only expressed in placenta. Isoform C and isoform D are expressed in a variety of tissues and cultured cells.|
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Fibulin 1 is a secreted glycoprotein that becomesincorporated into a fibrillar extracellular matrix. Calcium-bindingis apparently required to mediate its binding to laminin andnidogen. It mediates platelet adhesion via binding fibrinogen. Foursplice variants which differ in the 3' end have been identified.Each variant encodes a different isoform, but no functionaldistinctions have been identified among the four variants.
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Li, C., et al. Mol. Vis. 16, 689-697 (2010) :Wooten, E.C., et al. PLoS ONE 5 (1), E8830 (2010) :Argraves, W.S., et al. Histochem. Cell Biol. 132(5):559-565(2009)Piscaglia, F., et al. Cell Tissue Res. 337(3):449-462(2009)
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