|Other Names||Myosin regulatory light polypeptide 9, 20 kDa myosin light chain, LC20, MLC-2C, Myosin RLC, Myosin regulatory light chain 2, smooth muscle isoform, Myosin regulatory light chain 9, Myosin regulatory light chain MRLC1, MYL9, MLC2, MRLC1, MYRL2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||MLC2, MRLC1, MYRL2|
|Function||Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Implicated in cytokinesis, receptor capping, and cell locomotion.|
|Tissue Location||Smooth muscle tissues and in some, but not all, nonmuscle cells.|
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Provided below are standard protocols that you may find useful for product applications.
Myosin, a structural component of muscle, consists of twoheavy chains and four light chains. The protein encoded by thisgene is a myosin light chain that may regulate muscle contractionby modulating the ATPase activity of myosin heads. The encodedprotein binds calcium and is activated by myosin light chainkinase. Two transcript variants encoding different isoforms havebeen found for this gene.
Gilles, L., et al. Blood 114(19):4221-4232(2009)Higashihara, M., et al. J Smooth Muscle Res 44(1):29-40(2008)Szczesna-Cordary, D., et al. J. Cell. Sci. 118 (PT 16), 3675-3683 (2005) :Webb, R.C. Adv Physiol Educ 27 (1-4), 201-206 (2003) :Deloukas, P., et al. Nature 414(6866):865-871(2001)
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