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TMPRSS13 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9BYE2 |
|---|---|
| Clone Names | 100507097 |
| Gene ID | 84000 |
|---|---|
| Other Names | Transmembrane protease serine 13, 3421-, Membrane-type mosaic serine protease, Mosaic serine protease, TMPRSS13, MSP, TMPRSS11 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | TMPRSS13 |
|---|---|
| Synonyms | MSP, TMPRSS11 |
| Function | Serine protease (PubMed:20977675, PubMed:28710277, PubMed:34562451). Cleaves the proform of PRSS8/prostasin to form the active protein (PubMed:34562451). Cleaves the proform of HGF to form the active protein which promotes MAPK signaling (PubMed:20977675). Promotes the formation of the stratum corneum and subsequently the epidermal barrier in embryos (By similarity). |
| Cellular Location | Cell membrane; Single-pass type II membrane protein. Secreted. Cytoplasm Note=The non-phosphorylated, inactive full length protein localizes intracellularly (PubMed:28710277). N-glycosylation and phosphorylation is required for trafficking to the cell surface (PubMed:28710277, PubMed:34562451, PubMed:35796294). Interaction with SPINT1/HAI-1 and SPINT2/HAI-2 facilitate its translocation to the cell surface (PubMed:34562451, PubMed:35796294). Proteolytic cleavage is required for secretion (PubMed:35796294). |
| Tissue Location | Expressed in placenta. [Isoform 3]: Expressed in lung, placenta, pancreas, and prostate (PubMed:11267681). Weakly expressed in testis and peripheral blood lymphocytes (PubMed:11267681) |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
TMPRSS13 is a cell membrane serine protease. It is a member of a larger family of membrane attached serine proteases, a poorly defined group that includes TMPRSS11A, B, C, D, E, F, Hepsin, Corin, Matriptase 1, 2 and 3. TMPRSS13 has a domain structure of an aminoterminal cytoplasmic domain, which is much longer than the other TMPRSS family members, followed by a transmembrane domain, an SRCR domain (Scavenger receptor cysteine rich), an LDL receptor like domain, another SRCR domain, followed by the trypsin like serine protease domain. The cytoplasmic domain contains a number of tandem repeat elements, the function of which is not clear, but which may play a regulatory role.
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