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MSX2 Antibody (Center) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession P35548
Clone Names 100507122
Peptide ID 100507122
Additional Information
Gene ID 4488
Other Names Homeobox protein MSX-2, Homeobox protein Hox-8, MSX2, HOX8
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name MSX2
Synonyms HOX8
Function Acts as a transcriptional regulator in bone development. Represses the ALPL promoter activity and antogonizes the stimulatory effect of DLX5 on ALPL expression during osteoblast differentiation. Probable morphogenetic role. May play a role in limb-pattern formation. In osteoblasts, suppresses transcription driven by the osteocalcin FGF response element (OCFRE). Binds to the homeodomain-response element of the ALPL promoter.
Cellular Location Nucleus.
Research Areas
Citations (0)

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Background

This gene encodes a member of the muscle segment homeoboxgene family. The encoded protein is a transcriptional repressorwhose normal activity may establish a balance between survival andapoptosis of neural crest-derived cells required for propercraniofacial morphogenesis. The encoded protein may also have arole in promoting cell growth under certain conditions and may bean important target for the RAS signaling pathways. Mutations inthis gene are associated with parietal foramina 1 andcraniosynostosis type 2.

References

Nikopensius, T., et al. Birth Defects Res. Part A Clin. Mol. Teratol. 88(9):748-756(2010)Satoh, K., et al. J. Gastroenterol. 45(7):763-770(2010)Doi, T., et al. J. Pediatr. Surg. 45(6):1187-1191(2010)Jagomagi, T., et al. Eur. J. Oral Sci. 118(3):213-220(2010)Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :

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$ 80.00
Cat# BP14677c
Size:
Quantity:
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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