|Other Names||Homeobox protein MSX-2, Homeobox protein Hox-8, MSX2, HOX8|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Acts as a transcriptional regulator in bone development. Represses the ALPL promoter activity and antagonizes the stimulatory effect of DLX5 on ALPL expression during osteoblast differentiation. Probable morphogenetic role. May play a role in limb-pattern formation. In osteoblasts, suppresses transcription driven by the osteocalcin FGF response element (OCFRE). Binds to the homeodomain-response element of the ALPL promoter.|
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This gene encodes a member of the muscle segment homeoboxgene family. The encoded protein is a transcriptional repressorwhose normal activity may establish a balance between survival andapoptosis of neural crest-derived cells required for propercraniofacial morphogenesis. The encoded protein may also have arole in promoting cell growth under certain conditions and may bean important target for the RAS signaling pathways. Mutations inthis gene are associated with parietal foramina 1 andcraniosynostosis type 2.
Nikopensius, T., et al. Birth Defects Res. Part A Clin. Mol. Teratol. 88(9):748-756(2010)Satoh, K., et al. J. Gastroenterol. 45(7):763-770(2010)Doi, T., et al. J. Pediatr. Surg. 45(6):1187-1191(2010)Jagomagi, T., et al. Eur. J. Oral Sci. 118(3):213-220(2010)Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :
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