|Other Names||Interleukin-17D, IL-17D, Interleukin-27, IL-27, IL17D, IL27|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Induces expression of IL6, CXCL8/IL8, and CSF2/GM-CSF from endothelial cells.|
|Tissue Location||Expressed preferentially in adipose, skeletal muscle and CNS.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a cytokine that sharesthe sequence similarity with IL17. The treatment of endothelialcells with this cytokine has been shown to stimulate the productionof other cytokines including IL6, IL8 and CSF2/ GM-CSF. Theincreased expression of IL8 induced by this cytokine was found tobe NF-kappa B-dependent.
Davila, S., et al. Genes Immun. 11(3):232-238(2010)Fakruddin, J.M., et al. Blood 109(5):1841-1849(2007)Larousserie, F., et al. J. Immunol. 176(10):5890-5897(2006)Clark, H.F., et al. Genome Res. 13(10):2265-2270(2003)Starnes, T., et al. J. Immunol. 169(2):642-646(2002)
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