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KCNQ3 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | O43525 |
|---|---|
| Clone Names | 100507269 |
| Gene ID | 3786 |
|---|---|
| Other Names | Potassium voltage-gated channel subfamily KQT member 3, KQT-like 3, Potassium channel subunit alpha KvLQT3, Voltage-gated potassium channel subunit Kv73, KCNQ3 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | KCNQ3 (HGNC:6297) |
|---|---|
| Function | Associates with KCNQ2 or KCNQ5 to form a potassium channel with essentially identical properties to the channel underlying the native M-current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs. Therefore, it is important in the regulation of neuronal excitability. KCNQ2-KCNQ3 channel is selectively permeable to other cations besides potassium, in decreasing order of affinity K(+) > Rb(+) > Cs(+) > Na(+). Associates with Na(+)-coupled myo-inositol symporter SLC5A3 forming a coregulatory complex that alters ion selectivity, increasing Na(+) and Cs(+) permeation relative to K(+) permeation (PubMed:28793216). |
| Cellular Location | Cell membrane; Multi-pass membrane protein |
| Tissue Location | Predominantly expressed in brain. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
The M channel is a slowly activating and deactivatingpotassium channel that plays a critical role in the regulation ofneuronal excitability. The M channel is formed by the associationof the protein encoded by this gene and one of two related proteinsencoded by the KCNQ2 and KCNQ5 genes, both integral membraneproteins. M channel currents are inhibited by M1 muscarinicacetylcholine receptors and activated by retigabine, a novelanti-convulsant drug. Defects in this gene are a cause of benignfamilial neonatal convulsions type 2 (BFNC2), also known asepilepsy, benign neonatal type 2 (EBN2).
References
Bailey, S.D., et al. Diabetes Care (2010) In press :Gomez-Posada, J.C., et al. J. Neurosci. 30(27):9316-9323(2010)Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Hahn, A., et al. Brain Dev. 31(7):515-520(2009)
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