|Other Names||Transcription initiation factor TFIID subunit 7, RNA polymerase II TBP-associated factor subunit F, Transcription initiation factor TFIID 55 kDa subunit, TAF(II)55, TAFII-55, TAFII55, TAF7, TAF2F, TAFII55|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Functions as a component of the DNA-binding general transcription factor complex TFIID, a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. Present in both of the previously described TFIID species which either lack or contain TAFII30 (TFIID alpha and TFIID beta respectively).|
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Provided below are standard protocols that you may find useful for product applications.
The intronless gene for this transcription coactivator islocated between the protocadherin beta and gamma gene clusters onchromosome 5. The protein encoded by this gene is a component ofthe TFIID protein complex, a complex which binds to the TATA box inclass II promoters and recruits RNA polymerase II and otherfactors. This particular subunit interacts with the largest TFIIDsubunit, as well as multiple transcription activators. The proteinis required for transcription by promoters targeted by RNApolymerase II.
Gegonne, A., et al. Proc. Natl. Acad. Sci. U.S.A. 105(14):5367-5372(2008)Hartman, W.R., et al. Arch. Biochem. Biophys. 459(2):223-232(2007)Olsen, J.V., et al. Cell 127(3):635-648(2006)Olsen, J.V., et al. Cell 127(3):635-648(2006)Couture, J.F., et al. Nat. Struct. Mol. Biol. 13(2):140-146(2006)
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