TAF7 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q15545 |
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Clone Names | 100507282 |
Gene ID | 6879 |
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Other Names | Transcription initiation factor TFIID subunit 7, RNA polymerase II TBP-associated factor subunit F, Transcription initiation factor TFIID 55 kDa subunit, TAF(II)55, TAFII-55, TAFII55, TAF7, TAF2F, TAFII55 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | TAF7 |
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Synonyms | TAF2F, TAFII55 |
Function | The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription (PubMed:33795473). TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC) (PubMed:33795473). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 (PubMed:33795473, PubMed:10438527). TAF7 forms a promoter DNA binding subcomplex of TFIID, together with TAF1 and TAF2 (PubMed:33795473). Part of a TFIID complex containing TAF10 (TFIID alpha) and a TFIID complex lacking TAF10 (TFIID beta) (PubMed:10438527). |
Cellular Location | Nucleus {ECO:0000250|UniProtKB:Q9R1C0}. |
Tissue Location | Ubiquitous. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The intronless gene for this transcription coactivator islocated between the protocadherin beta and gamma gene clusters onchromosome 5. The protein encoded by this gene is a component ofthe TFIID protein complex, a complex which binds to the TATA box inclass II promoters and recruits RNA polymerase II and otherfactors. This particular subunit interacts with the largest TFIIDsubunit, as well as multiple transcription activators. The proteinis required for transcription by promoters targeted by RNApolymerase II.
References
Gegonne, A., et al. Proc. Natl. Acad. Sci. U.S.A. 105(14):5367-5372(2008)Hartman, W.R., et al. Arch. Biochem. Biophys. 459(2):223-232(2007)Olsen, J.V., et al. Cell 127(3):635-648(2006)Olsen, J.V., et al. Cell 127(3):635-648(2006)Couture, J.F., et al. Nat. Struct. Mol. Biol. 13(2):140-146(2006)
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