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TRA2B Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P62995 |
|---|---|
| Clone Names | 100507289 |
| Gene ID | 6434 |
|---|---|
| Other Names | Transformer-2 protein homolog beta, TRA-2 beta, TRA2-beta, hTRA2-beta, Splicing factor, arginine/serine-rich 10, Transformer-2 protein homolog B, TRA2B, SFRS10 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | TRA2B (HGNC:10781) |
|---|---|
| Synonyms | SFRS10 |
| Function | Sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing. Can either activate or suppress exon inclusion. Acts additively with RBMX to promote exon 7 inclusion of the survival motor neuron SMN2. Activates the splicing of MAPT/Tau exon 10. Alters pre-mRNA splicing patterns by antagonizing the effects of splicing regulators, like RBMX. Binds to the AG-rich SE2 domain in the SMN exon 7 RNA. Binds to pre-mRNA. |
| Cellular Location | Nucleus |
| Tissue Location | Highest expression in heart, skeletal muscle and pancreas. Less abundant in kidney, placenta and brain. Lowest expression in kidney and liver. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
TRA2B is a sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing.
References
Benderska, N., et al. Biochim. Biophys. Acta 1799 (5-6), 448-453 (2010) :Thorleifsson, G., et al. Nat. Genet. 41(1):18-24(2009)Caporaso, N., et al. PLoS ONE 4 (2), E4653 (2009) :Gabriel, B., et al. Acta Obstet Gynecol Scand 88(2):216-221(2009)Miele, A., et al. J. Cell. Biochem. 102(1):136-148(2007)
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