ALDH3A2 Blocking Peptide (N-term)
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | P51648 |
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Gene ID | 224 |
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Other Names | Fatty aldehyde dehydrogenase, Aldehyde dehydrogenase 10, Aldehyde dehydrogenase family 3 member A2, Microsomal aldehyde dehydrogenase, ALDH3A2, ALDH10, FALDH |
Target/Specificity | The synthetic peptide sequence is selected from aa 30-44 of HUMAN ALDH3A2 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | ALDH3A2 |
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Function | Catalyzes the oxidation of medium and long chain aliphatic aldehydes to fatty acids. Active on a variety of saturated and unsaturated aliphatic aldehydes between 6 and 24 carbons in length (PubMed:9133646, PubMed:22633490, PubMed:25047030, PubMed:18035827, PubMed:9662422, PubMed:18182499). Responsible for conversion of the sphingosine 1-phosphate (S1P) degradation product hexadecenal to hexadecenoic acid (PubMed:22633490). |
Cellular Location | Microsome membrane; Single-pass membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein; Cytoplasmic side {ECO:0000250|UniProtKB:P30839} |
Tissue Location | Detected in liver (at protein level). |
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Provided below are standard protocols that you may find useful for product applications.
Background
Aldehyde dehydrogenase isozymes are thought to play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. ALDH3A2 catalyzes the oxidation of long-chain aliphatic aldehydes to fatty acid. Mutations in the gene cause Sjogren-Larsson syndrome.
References
Chang, C., et al., Genomics 40(1):80-85 (1997).
Rogers, G.R., et al., Genomics 39(2):127-135 (1997).
De Laurenzi, V., et al., Nat. Genet. 12(1):52-57 (1996).
Rogers, G.R., et al., Am. J. Hum. Genet. 57(5):1123-1129 (1995).
Pigg, M., et al., Nat. Genet. 8(4):361-364 (1994).
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