|Other Names||Fatty aldehyde dehydrogenase, Aldehyde dehydrogenase 10, Aldehyde dehydrogenase family 3 member A2, Microsomal aldehyde dehydrogenase, ALDH3A2, ALDH10, FALDH|
|Target/Specificity||The synthetic peptide sequence is selected from aa 30-44 of HUMAN ALDH3A2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes the oxidation of long-chain aliphatic aldehydes to fatty acids. Active on a variety of saturated and unsaturated aliphatic aldehydes between 6 and 24 carbons in length. Responsible for conversion of the sphingosine 1-phosphate (S1P) degradation product hexadecenal to hexadecenoic acid.|
|Cellular Location||Endoplasmic reticulum membrane; Single-pass membrane protein; Cytoplasmic side|
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Provided below are standard protocols that you may find useful for product applications.
Aldehyde dehydrogenase isozymes are thought to play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. ALDH3A2 catalyzes the oxidation of long-chain aliphatic aldehydes to fatty acid. Mutations in the gene cause Sjogren-Larsson syndrome.
Chang, C., et al., Genomics 40(1):80-85 (1997).
Rogers, G.R., et al., Genomics 39(2):127-135 (1997).
De Laurenzi, V., et al., Nat. Genet. 12(1):52-57 (1996).
Rogers, G.R., et al., Am. J. Hum. Genet. 57(5):1123-1129 (1995).
Pigg, M., et al., Nat. Genet. 8(4):361-364 (1994).
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