Mouse Acvrl1 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q61288 |
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Clone Names | 110316030 |
Gene ID | 11482 |
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Other Names | Serine/threonine-protein kinase receptor R3, SKR3, Activin receptor-like kinase 1, ALK-1, TGF-B superfamily receptor type I, TSR-I, Acvrl1, Acvrlk1, Alk-1 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | Acvrl1 |
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Synonyms | Acvrlk1, Alk-1 |
Function | Type I receptor for TGF-beta family ligands BMP9/GDF2 and BMP10 and important regulator of normal blood vessel development. On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. May bind activin as well. |
Cellular Location | Cell membrane {ECO:0000250|UniProtKB:P37023}; Single-pass type I membrane protein |
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Provided below are standard protocols that you may find useful for product applications.
Background
On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for TGF-beta. May bind activin as well.
References
Luo, J., et al. J. Biol. Chem. 285(38):29588-29598(2010)Suzuki, Y., et al. J. Cell. Sci. 123 (PT 10), 1684-1692 (2010) :Niessen, K., et al. Blood 115(8):1654-1661(2010)Mitchell, D., et al. Mol. Cancer Ther. 9(2):379-388(2010)Cunha, S.I., et al. J. Exp. Med. 207(1):85-100(2010)
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