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Mouse Acvrl1 Antibody (C-term) Blocking Peptide

Synthetic peptide

     
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  • CITATIONS
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Product Information
Primary Accession Q61288
Clone Names 110316030
Additional Information
Gene ID 11482
Other Names Serine/threonine-protein kinase receptor R3, SKR3, Activin receptor-like kinase 1, ALK-1, TGF-B superfamily receptor type I, TSR-I, Acvrl1, Acvrlk1, Alk-1
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name Acvrl1
Synonyms Acvrlk1, Alk-1
Function Type I receptor for TGF-beta family ligands BMP9/GDF2 and BMP10 and important regulator of normal blood vessel development. On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. May bind activin as well.
Cellular Location Cell membrane {ECO:0000250|UniProtKB:P37023}; Single-pass type I membrane protein
Research Areas
Citations (0)
citation

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Background

On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for TGF-beta. May bind activin as well.

References

Luo, J., et al. J. Biol. Chem. 285(38):29588-29598(2010)Suzuki, Y., et al. J. Cell. Sci. 123 (PT 10), 1684-1692 (2010) :Niessen, K., et al. Blood 115(8):1654-1661(2010)Mitchell, D., et al. Mol. Cancer Ther. 9(2):379-388(2010)Cunha, S.I., et al. J. Exp. Med. 207(1):85-100(2010)

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$ 277.78
Cat# BP14702b
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