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Mouse Aurkc Antibody (C-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession O88445
Clone Names 110316048
Peptide ID 110316048
Additional Information
Other Names Aurora kinase C, Aurora 3, Aurora/IPL1-related kinase 3, ARK-3, Aurora-related kinase 3, Aurora/IPL1/Eg2 protein 1, Serine/threonine-protein kinase 13, Serine/threonine-protein kinase aurora-C, Aurkc, Aie1, Aik3, Airk3, Ark3, Stk13
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name Aurkc
Synonyms Aie1, Aik3, Airk3, Ark3, Stk13
Function Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Plays also a role in meiosis and more particularly in spermatogenesis. Has redundant cellular functions with AURKB and can rescue an AURKB knockdown. Like AURKB, AURKC phosphorylates histone H3 at 'Ser-10' and 'Ser-28'. Phosphorylates TACC1, another protein involved in cell division, at 'Ser-228'.
Cellular Location Nucleus. Chromosome. Chromosome, centromere. Cytoplasm, cytoskeleton, spindle. Note=Distributes in the condensed chromosomes during prophase to metaphase. After entering anaphase, there is a dissociation from separated chromosomes and a redistribution to midzone microtubules, and finally remains in the midbody during cytokinesis (By similarity).
Tissue Location Expressed only in testis.
Research Areas
Citations (0)

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Aurkc may play a part in organizing microtubules in relation to the function of the centrosome/spindle pole during mitosis.

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$ 80.00
Cat# BP14704b
(40 western blots)
Availability: In Stock
Bulk Size
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