|Other Names||Casein kinase I isoform delta, CKI-delta, CKId, Tau-protein kinase CSNK1D, Csnk1d, Hckid|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Essential serine/threonine-protein kinase that regulates diverse cellular growth and survival processes including Wnt signaling, DNA repair and circadian rhythms. It can phosphorylate a large number of proteins. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Phosphorylates connexin-43/GJA1, MAP1A, SNAPIN, MAPT/TAU, TOP2A, DCK, HIF1A, EIF6, p53/TP53, DVL2, DVL3, ESR1, AIB1/NCOA3, DNMT1, PKD2, YAP1, PER1 and PER2. Central component of the circadian clock. In balance with PP1, determines the circadian period length through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. Controls PER1 and PER2 nuclear transport and degradation. YAP1 phosphorylation promotes its SCF(beta-TRCP) E3 ubiquitin ligase-mediated ubiquitination and subsequent degradation. DNMT1 phosphorylation reduces its DNA-binding activity. Phosphorylation of ESR1 and AIB1/NCOA3 stimulates their activity and coactivation. Phosphorylation of DVL2 and DVL3 regulates WNT3A signaling pathway that controls neurite outgrowth. EIF6 phosphorylation promotes its nuclear export. Triggers down-regulation of dopamine receptors in the forebrain. Activates DCK in vitro by phosphorylation. TOP2A phosphorylation favors DNA cleavable complex formation. May regulate the formation of the mitotic spindle apparatus in extravillous trophoblast. Modulates connexin-43/GJA1 gap junction assembly by phosphorylation. Probably involved in lymphocyte physiology. Regulates fast synaptic transmission mediated by glutamate.|
|Cellular Location||Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, perinuclear region. Cell membrane Cytoplasm, cytoskeleton, spindle. Golgi apparatus. Note=Localized at mitotic spindle microtubules, and at the centrosomes and interphase in interphase cells. Recruited to the spindle apparatus and the centrosomes in response to DNA- damage. Correct subcellular localization requires kinase activity (By similarity).|
|Tissue Location||Expressed ubiquitously. However, kinase activity is not uniform, with highest kinase activity in splenocytes.|
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This gene encodes a member of the casein kinase I (CKI)family of serine/threonine protein kinases. A highly similar humanprotein regulates an array of cellular processes by influencing theWnt and hedgehog signaling pathways. The encoded protein may alsobe involved in the regulation of apoptosis, circadian rhythm,microtubule dynamics, chromosome segregation, and p53-mediatedeffects on growth. Alternatively spliced transcript variantsencoding different isoforms have been described. [provided byRefSeq].
Sugiyama, Y., et al. Biochem. J. 427(3):489-497(2010)Etchegaray, J.P., et al. PLoS ONE 5 (4), E10303 (2010) :Lee, H., et al. Proc. Natl. Acad. Sci. U.S.A. 106(50):21359-21364(2009)Martinez, G., et al. Invest. Ophthalmol. Vis. Sci. 50(10):4794-4806(2009)Isojima, Y., et al. Proc. Natl. Acad. Sci. U.S.A. 106(37):15744-15749(2009)
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