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ERAS Antibody (N-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q7Z444
Clone Names 70319173
Peptide ID 70319173
Additional Information
Gene ID 3266
Other Names GTPase ERas, E-Ras, Embryonic stem cell-expressed Ras, ERAS, HRAS2, HRASP
Target/Specificity The synthetic peptide sequence used to generate the antibody AP1470a was selected from the N-term region of human ERAS. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms HRAS2, HRASP
Function Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays an important role in the tumor-like growth properties of embryonic stem cells (By similarity).
Cellular Location Cell membrane; Lipid-anchor; Cytoplasmic side
Research Areas
Citations (0)

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Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Point mutations of several amino acids of human RAS, including gly12, ala59, or glu63, render the protein constitutively active. Embryonic stem cell-expressed Ras (ERAS) has serine, alanine, and asparagine at the positions corresponding to gly12, ala59, and glu63 of human RAS, suggesting that it is constitutively active.The PI3K (phosphoinositide 3-kinase) pathway is important for proliferation, survival and maintenance of pluripotency in ES cells. The PI3K pathway is activated by growth factors and cytokines including insulin and leukaemia inhibitory factor. In addition to these exogenous factors, the PI3K pathway is endogenously activated by the constitutively active Ras family protein ERas (ES cell-expressed Ras). ERas null ES cells maintained pluripotency but show significantly reduced growth and tumorigenicity, which can be rescued by expression of ERas cDNA or by activated phosphatidylinositol 3-hydroxykinase. The transforming oncogene ERAS appears to be important in the tumor-like growth properties of ES cells.


Kameda,T., Stem Cells 23 (10), 1535-1540 (2005)Takahashi,K., Nature 423 (6939), 541-545 (2003)Miyoshi,J., Nucleic Acids Res. 12 (4), 1821-1828 (1984)

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$ 80.00
Cat# BP1470a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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