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Mouse Dyrk3 Antibody (N-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q922Y0
Clone Names 110316134
Peptide ID 110316134
Additional Information
Gene ID 226419
Other Names Dual specificity tyrosine-phosphorylation-regulated kinase 3, Dyrk3 {ECO:0000312|MGI:MGI:1330300}
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name Dyrk3 {ECO:0000312|MGI:MGI:1330300}
Function Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities. Negative regulator of EPO-dependent erythropoiesis, may place an upper limit on red cell production during stress erythropoiesis. Inhibits cell death due to cytokine withdrawal in hematopoietic progenitor cells (By similarity). May act by regulating CREB/CRE signaling (PubMed:12356771). Stabilizes and prevents stress granule disassembly thereby regulating mTORC1 signaling during cellular stress. During stressful conditions, DYRK3 partitions to the stress granule from the cytosol, as well as mTORC1 components, which prevents mTORC1 signaling. When stress signals are gone, the kinase activity of DYRK3 is required for the dissolution of stress granule and mTORC1 relocation to the cytosol, and promotes the phosphorylation of the mTORC1 inhibitor, AKT1S1, allowing full reactivation of mTORC1 signaling. Promotes cell survival upon genotoxic stress through phosphorylation of SIRT1. This in turn inhibits TP53 activity and apoptosis (By similarity).
Cellular Location Nucleus {ECO:0000250|UniProtKB:O43781}. Cytoplasmic granule {ECO:0000250|UniProtKB:O43781}. Note=Shuttles between cytoplasm and stress granules. Localized predominantly on distinct speckles distributed throughout the cytoplasm of the cell. At low concentration, showns a homogeneous distribution throughout the cytoplasm and does not condense in speckles. During oxidative and osmotic stress, localizes to stress granules (By similarity). {ECO:0000250|UniProtKB:O43781}
Research Areas
Citations (0)

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Background

Negative regulator of EPO-dependent erythropoiesis, may place an upper limit on red cell production during stress erythropoiesis. Inhibits cell death due to cytokine withdrawal in hematopoietic progenitor cells. May act by regulating CREB/CRE signaling.

References

Guo, X., et al. J. Biol. Chem. 285(17):13223-13232(2010)Bogacheva, O., et al. J. Biol. Chem. 283(52):36665-36675(2008)Wojchowski, D.M., et al. Blood Cells Mol. Dis. 36(2):232-238(2006)Zhang, D., et al. Genomics 85(1):117-130(2005)Li, K., et al. J. Biol. Chem. 277(49):47052-47060(2002)

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$ 80.00
Cat# BP14712a
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