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KDELR2 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P33947 |
|---|---|
| Clone Names | 100324233 |
| Gene ID | 11014 |
|---|---|
| Other Names | ER lumen protein-retaining receptor 2, ERD2-like protein 1, ELP-1, KDEL endoplasmic reticulum protein retention receptor 2, KDEL receptor 2, KDELR2, ERD22 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | KDELR2 |
|---|---|
| Synonyms | ERD2.2 {ECO:0000303|PubMed:1325562} |
| Function | Membrane receptor that binds the K-D-E-L sequence motif in the C-terminal part of endoplasmic reticulum resident proteins and maintains their localization in that compartment by participating to their vesicle-mediated recycling back from the Golgi (PubMed:1325562, PubMed:18086916, PubMed:33053334). Binding is pH dependent, and is optimal at pH 5-5.4 (By similarity). |
| Cellular Location | Endoplasmic reticulum membrane; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q5ZKX9}. Golgi apparatus membrane; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q5ZKX9}. Cytoplasmic vesicle, COPI-coated vesicle membrane; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q5ZKX9} Note=Localized in the Golgi in the absence of bound proteins with the sequence motif K-D-E-L. Trafficks back to the endoplasmic reticulum together with cargo proteins containing the sequence motif K-D-E-L |
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Provided below are standard protocols that you may find useful for product applications.
Background
Retention of resident soluble proteins in the lumen of theendoplasmic reticulum (ER) is achieved in both yeast and animalcells by their continual retrieval from the cis-Golgi, or apre-Golgi compartment. Sorting of these proteins is dependent on aC-terminal tetrapeptide signal, usually lys-asp-glu-leu (KDEL) inanimal cells, and his-asp-glu-leu (HDEL) in S. cerevisiae. Thisprocess is mediated by a receptor that recognizes, and binds thetetrapeptide-containing protein, and returns it to the ER. Inyeast, the sorting receptor encoded by a single gene, ERD2, is aseven-transmembrane protein. Unlike yeast, several human homologsof the ERD2 gene, constituting the KDEL receptor gene family, havebeen described. KDELR2 was the second member of the family to beidentified, and it encodes a protein which is 83% identical to theKDELR1 gene product. Alternative splicing results in multipletranscript variants encoding distinct isoforms. [provided byRefSeq].
References
van der Vlies, D., et al. Biochem. J. 366 (PT 3), 825-830 (2002) :Pelham, H.R. Cell Struct. Funct. 21(5):413-419(1996)Lewis, M.J., et al. J. Mol. Biol. 226(4):913-916(1992)Hsu, V.W., et al. Cell 69(4):625-635(1992)
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