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USP30 Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q70CQ3 |
|---|---|
| Clone Names | 100406235 |
| Gene ID | 84749 |
|---|---|
| Other Names | Ubiquitin carboxyl-terminal hydrolase 30, Deubiquitinating enzyme 30, Ubiquitin thioesterase 30, Ubiquitin-specific-processing protease 30, Ub-specific protease 30, USP30 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | USP30 (HGNC:20065) |
|---|---|
| Function | Deubiquitinating enzyme tethered to the mitochondrial outer membrane that acts as a key inhibitor of mitophagy by counteracting the action of parkin (PRKN): hydrolyzes ubiquitin attached by parkin on target proteins, such as RHOT1/MIRO1 and TOMM20, thereby blocking parkin's ability to drive mitophagy (PubMed:18287522, PubMed:24896179, PubMed:25527291, PubMed:25621951). Preferentially cleaves 'Lys-6'- and 'Lys-11'-linked polyubiquitin chains, 2 types of linkage that participate in mitophagic signaling (PubMed:25621951). Does not cleave efficiently polyubiquitin phosphorylated at 'Ser-65' (PubMed:25527291). Acts as a negative regulator of mitochondrial fusion by mediating deubiquitination of MFN1 and MFN2 (By similarity). |
| Cellular Location | Mitochondrion outer membrane |
| Tissue Location | Expressed in skeletal muscle, pancreas, liver and kidney. |
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Provided below are standard protocols that you may find useful for product applications.
Background
USP30, a member of the ubiquitin-specific protease family(see USP1, MIM 603478), is a novel mitochondrial deubiquitinating(DUB) enzyme (Nakamura and Hirose, 2008 [PubMed18287522]).
References
Nakamura, N., et al. Mol. Biol. Cell 19(5):1903-1911(2008)Quesada, V., et al. Biochem. Biophys. Res. Commun. 314(1):54-62(2004)Puente, X.S., et al. Nat. Rev. Genet. 4(7):544-558(2003)
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