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C4orf49 Antibody (C-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q8TDB4
Clone Names 100408034
Peptide ID 100408034
Additional Information
Other Names Protein MGARP, Corneal endothelium-specific protein 1, CESP-1, Hypoxia up-regulated mitochondrial movement regulator protein, Mitochondria-localized glutamic acid-rich protein, Ovary-specific acidic protein, MGARP, C4orf49, CESP1, HUMMR, OSAP
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name MGARP
Synonyms C4orf49, CESP1, HUMMR, OSAP
Function Plays a role in the trafficking of mitochondria along microtubules. Regulates the kinesin-mediated axonal transport of mitochondria to nerve terminals along microtubules during hypoxia. Participates in the translocation of TRAK2/GRIF1 from the cytoplasm to the mitochondrion. Also plays a role in steroidogenesis through maintenance of mitochondrial abundance and morphology (By similarity).
Cellular Location Mitochondrion. Mitochondrion outer membrane {ECO:0000250|UniProtKB:Q8VI64}; Single-pass type IV membrane protein {ECO:0000250|UniProtKB:Q8VI64}; Cytoplasmic side {ECO:0000250|UniProtKB:Q8VI64}. Note=Colocalizes with RHOT1, RHOT2, TRAK1 and TRAK2 at the mitochondrion {ECO:0000250|UniProtKB:Q8VI64}
Tissue Location Expressed in the brain, adrenal gland and corneal endothelium (CE). Expressed in steroid-producing cells of the ovary and testis (at protein level). Expressed in steroid- producing cells of the ovary and testis. Weakly expressed in placenta. Expressed in corneal endothelial cells EMBL; AF484960; AAM09685.1; -; mRNA EMBL; AF329088; AAG59896.1; -; mRNA EMBL; CH471056; EAX05122.1; -; Genomic_DNA EMBL; BC104173; AAI04174.1; -; mRNA EMBL; BC104174; AAI04175.1; -; mRNA CCDS; CCDS43269.1; - RefSeq; NP_116012.2; NM_032623.3 UniGene; Hs.710036; - ProteinModelPortal; Q8TDB4; - SMR; Q8TDB4; - BioGrid; 124220; 2 IntAct; Q8TDB4; 3 STRING; 9606.ENSP00000381928; - iPTMnet; Q8TDB4; - PhosphoSitePlus; Q8TDB4; - BioMuta; MGARP; - DMDM; 74715889; - EPD; Q8TDB4; - PaxDb; Q8TDB4; - PeptideAtlas; Q8TDB4; - PRIDE; Q8TDB4; - Ensembl; ENST00000398955; ENSP00000381928; ENSG00000137463 GeneID; 84709; - KEGG; hsa:84709; - UCSC; uc003ihr.1; human CTD; 84709; - DisGeNET; 84709; - GeneCards; MGARP; - H-InvDB; HIX0200666; - HGNC; HGNC:29969; MGARP HPA; HPA015994; - neXtProt; NX_Q8TDB4; - OpenTargets; ENSG00000137463; - PharmGKB; PA164717327; - eggNOG; ENOG410IWK1; Eukaryota eggNOG; ENOG410Y7BU; LUCA GeneTree; ENSGT00440000037338; - HOGENOM; HOG000111473; - InParanoid; Q8TDB4; - OMA; HTEHITN; - OrthoDB; EOG091G0YRU; - PhylomeDB; Q8TDB4; - TreeFam; TF336324; - GenomeRNAi; 84709; - PRO; PR:Q8TDB4; - Proteomes; UP000005640; Chromosome 4 Bgee; ENSG00000137463; - Genevisible; Q8TDB4; HS GO; GO:1904115; C:axon cytoplasm; IEA:GOC GO; GO:0031307; C:integral component of mitochondrial outer membrane; ISS:UniProtKB GO; GO:0005739; C:mitochondrion; IDA:UniProtKB GO; GO:0008089; P:anterograde axonal transport; ISS:UniProtKB GO; GO:0019896; P:axonal transport of mitochondrion; ISS:UniProtKB GO; GO:0097211; P:cellular response to gonadotropin-releasing hormone; ISS:UniProtKB GO; GO:0071456; P:cellular response to hypoxia; ISS:UniProtKB GO; GO:0071383; P:cellular response to steroid hormone stimulus; ISS:UniProtKB GO; GO:0010822; P:positive regulation of mitochondrion organization; ISS:UniProtKB GO; GO:0006626; P:protein targeting to mitochondrion; ISS:UniProtKB GO; GO:0010821; P:regulation of mitochondrion organization; IBA:GO_Central GO; GO:0008090; P:retrograde axonal transport; ISS:UniProtKB InterPro; IPR026093; MGARP InterPro; IPR032773; MGARP_N PANTHER; PTHR22910; PTHR22910; 1 Pfam; PF14962; AIF-MLS; 1 1: Evidence at protein level; Complete proteome; Membrane; Mitochondrion; Mitochondrion outer membrane; Polymorphism; Reference proteome; Transmembrane; Transmembrane helix CHAIN 1 240 Protein MGARP /FTId=PRO_0000318764 TOPO_DOM 1 40 Cytoplasmic. TRANSMEM 41 63 Helical; Anchor for type IV membrane protein. TOPO_DOM 64 240 Mitochondrial intermembrane VARIANT 128 128 A -> T (in dbSNP:rs3208941) /FTId=VAR_051256 CONFLICT 240 240 G -> RANLQPVDISATNAIGCLISAFVFLVHLV (in Ref. 2; AAG59896). SEQUENCE 240 AA; 25390 MW; 6E210FA627635CEC CRC64; MYLRRAVSKT LALPLRAPPN PAPLGKDASL RRMSSNRFPG SSGSNMIYYL VVGVTVSAGG YYAYKTVTSD QAKHTEHKTN LKEKTKAEIH PFQGEKENVA ETEKASSEAP EELIVEAEVV DAEESPSATV VVIKEASACP GHVEAAPETT AVSAETGPEV TDAAARETTE VNPETTPEVT NAALDEAVTI DNDKDTTKNE TSDEYAELEE ENSPAESESS AGDDLQEEAS VGSEAASAQG
Research Areas
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Background

The function of this protein remains unknown.

References

Matsumoto, T., et al. Endocrinology 150(7):3353-3359(2009)Li, Y., et al. J. Cell Biol. 185(6):1065-1081(2009)Kinouchi, R., et al. Invest. Ophthalmol. Vis. Sci. 47(4):1397-1403(2006)Sakai, R., et al. Invest. Ophthalmol. Vis. Sci. 43(6):1749-1756(2002)

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$ 80.00
Cat# BP14729b
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